Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Cristiano Alpigiani, Adrian Bevan, Marcella Bona, Marco Ciuchini, Denis Derkach, et al.. Unitarity Triangle Analysis in the Standard Model and Beyond. 5th Large Hadron Collider Physics Conference, May 2017, Shanghai, China. ⟨hal-02410853⟩
  • G. de France, A. Blanc, F. Drouet, M. Jentschel, U. Köster, et al.. EXOGAM at the ILL: the EXILL campaign . 12th International Spring Seminar on Nuclear Physics Current Problems and Prospects for Nuclear Structure, May 2017, Sant'Angelo d'Ischia, Italy. pp.012012, ⟨10.1088/1742-6596/966/1/012012⟩. ⟨in2p3-01526110⟩
  • Iryna Chaikovska, Xavier Artru, Robert Chehab, Kazuro Furukawa, Hayg Guler, et al.. Experimental Activities on High Intensity Positron Sources Using Channeling. 8th International Particle Accelerator Conference, May 2017, Copenhagen, Denmark. pp.WEPIK002, ⟨10.18429/JACoW-IPAC2017-WEPIK002⟩. ⟨hal-01645354⟩
  • Hugues Lattaud. Gamma + jet, residual jet energy correction. Helsinki JetMet workshop physics at 100fb-1, May 2017, Helsinki, Finland. ⟨hal-02023481⟩
  • Nils Krah, Mauro Testa, Simon Rit, Ilaria Rinaldi. How much can range accuracy in proton therapy be improved through patient specific optimization of the HU-RSP conversion curve?. 56th annual confĂ©rence of the Particle Therapy Co-operative Group - PTCOG 56, May 2017, Pacifico Yokohama, Yokohama, Japan. ⟨10.14338/IJPT.17-PTCOG-1.1⟩. ⟨hal-01714201⟩
  • Nils Krah, L. de Marzi, Annalisa Patriarca, G. Pitta, Ilaria Rinaldi. Plug’n’play proton radiography with commercial QA equipment - A first hand practical how-to . 56th annual confĂ©rence of the Particle Therapy Co-operative Group - PTCOG 56, May 2017, Yokohama, Japan. 2017. ⟨hal-01795522⟩
  • Brent Huisman, David Sarrut, Etienne Testa, Nils Krah. Performance of prompt gamma fall-off detection in clinical simulations. 56th annual confĂ©rence of the Particle Therapy Co-operative Group - PTCOG 56, May 2017, Pacifico Yokohama, Yokohama, Japan. 2017. ⟨hal-01714304⟩
  • S. Pandeti, L. Feketeova, T. Narender, T.J. Reddy, H. Abdoul-Carime, et al.. Understanding the action of radiosensitizers in radiotherapy by mass spectrometry and theory. 35th Informal Meeting on Mass Spectrometry, May 2017, Aussois, France. ⟨in2p3-02087334⟩
  • S. Beauceron. search for VLQ in single production. TOP LHC France, May 2017, Marseille, France. ⟨hal-02063429⟩
  • M.Ali Mirzaei, Vincent Voisin, Alberto Annovi, Guillaume Baulieu, Matteo Beretta, et al.. Heterogeneous computing system platform for high-performance pattern recognition applications. 6th International Conference on Modern Circuits and Systems Technologies, May 2017, Thessaloniki, Greece. pp.7937638, ⟨10.1109/MOCAST.2017.7937638⟩. ⟨hal-01669640⟩

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