Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- Mattia Fontana, Jean-Luc Ley, Etienne Testa, Jean Michel Létang, Voichita Maxim, et al.. Versatile Compton camera for high energy gamma rays: Monte Carlo comparison with Anger camera for medical imaging. 2nd Jagiellonan Symposium on Fundamental and Applied Subatomic Physics, Jun 2017, Krakow, Poland. pp.1639-1645, ⟨10.5506/APhysPolB.48.1639⟩. ⟨hal-01609541⟩
- Caterina Monini, Etienne Testa, Michael Beuve. NanOxTM , a new multiscale model to predict ion RBE in hadrontherapy. 2nd Jagiellonian Symposium of Fundamental and Applied Subatomic Physics, Jun 2017, Krakow, Poland. ⟨hal-02049090⟩
- C. Monini, E. Testa, M. Beuve. NanOx TM : a new multiscale model to predict ion RBE in hadrontherapy. 2nd Jagiellonian Symposium on Fundamental and Applied Subatomic Physics, Jun 2017, Krakow, Poland. ⟨hal-01609479⟩
- R. Caravita, S. Aghion, C. Amsler, G. Bonomi, R.S. Brusa, et al.. Advances in Ps Manipulations and Laser Studies in the AEgIS Experiment. 2nd Jagiellonian Symposium of Fundamental and Applied Subatomic Physics, Jun 2017, Kraków, Poland. pp.1583, ⟨10.5506/APhysPolB.48.1583⟩. ⟨hal-01704756⟩
- C. Gaillard, Maria Yu Boltoeva. Les liquides ioniques pour l'extraction liquide-liquide des ions métalliques. Réunion plénière GDR Prométhée, May 2017, Nancy, France. ⟨in2p3-02097711⟩
- Emeline Queguiner. Low-Mass WIMP Search with the EDELWEISS experiment: Latest Results and Developments. 29th Rencontres de Blois, May 2017, Blois, France. ⟨hal-02060159⟩
- Yuwei Zhu, M. Abaline, S. Acounis, N. Beaupère, J.L. Beney, et al.. Scintillation Signal in XEMIS2, a Liquid Xenon Compton Camera with 3γ Imaging Technique. 4th International conference on Technology and Instrumentation in Particle Physics, May 2017, Beijing, China. pp.159-163, ⟨10.1007/978-981-13-1316-5_30⟩. ⟨hal-01863099⟩
- Y. Xing, M. Abaline, S. Acounis, N. Beaupère, J.L. Beney, et al.. XEMIS: Liquid Xenon Compton Camera for 3γ Imaging. 4th International conference on Technology and Instrumentation in Particle Physics, May 2017, Beijing, China. pp.154-158, ⟨10.1007/978-981-13-1316-5_29⟩. ⟨hal-01863097⟩
- Yuwei Zhu, M. Abaline, S. Acounis, N. Beaupère, J.L. Beney, et al.. Scintillation Signal in XEMIS2, a Liquid Xenon Compton Camera with 3γ Imaging Technique. 4th International conference on Technology and Instrumentation in Particle Physics, May 2017, Beijing, China. ⟨hal-02292251⟩
- Brent Huisman. Accelerated Clinical Prompt Gamma simulations for Proton Therapy. Medical Physics [physics.med-ph]. INSA Lyon, 2017. English. ⟨NNT : ⟩. ⟨tel-01720881⟩
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