Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- S. Marcatili, A. Bès, G. Bosson, J. Collot, S. Curtoni, et al.. Développement d’un hodoscope diamant au LPSC. journée moniteurs faisceau du GDR MI2B, Jun 2017, Paris, France. ⟨hal-01609534⟩
- Claire Rodriguez-Lafrasse. Differential superiority of carbon ion irradiation and radiosensitizing nanoparticles to X-Rays: studies on biological effectiveness in tumor cell models . OIST Invited Conference, Jun 2017, Okinawa, Japan. ⟨hal-01609994⟩
- Anne-Sophie Wozny, Claire Rodriguez-Lafrasse. Role of HIF-1α in the resistance of Cancer Stem Cells to photon and carbon ion irradiations. OIST Invited conference, Jun 2017, Okinawa, Japan. ⟨hal-01609990⟩
- D. Autiero. ProtoDUNE−DP/1x1x3 m3 update. Long Baseline Neutrino Committee meeting, Jun 2017, Genève, Switzerland. ⟨in2p3-02108211⟩
- M.L. Gallin-Martel, L. Abbassi, A. Bes, G. Bosson, J. Collot, et al.. A large area diamond‐based beam tagging hodoscope for ion therapy monitoring. International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications (ANIMMA 2017), Jun 2017, Liège, Belgium. pp.09005, ⟨10.1051/epjconf/201817009005⟩. ⟨in2p3-01541626⟩
- Anne-Sophie Wozny, Michael Beuve, Yannick Saintigny, Tetsuo Nakajima, Guillaume Vares, et al.. Role of HIF-1α in the resistance of Cancer Stem Cells to photon and carbon ion irradiations. 15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Jun 2017, Ermatingen, Switzerland. 2017. ⟨hal-01738699⟩
- Mattia Fontana, Denis Dauvergne, Jochen Krimmer, Jean Michel Létang, Jean-Luc Ley, et al.. Comparison between Anger and Compton cameras for medical imaging: a Monte Carlo simulation study. 56èmes Journées Scientifiques de la SFPM, Jun 2017, Lyon, France. 2017. ⟨hal-01609928⟩
- M.L. Gallin-Martel, A. Bes, G. Bosson, J. Collot, S. Curtoni, et al.. Large area polycrystalline diamond detectors for online hadron therapy beam tagging applications. Journée Thématique du Réseau Semi-conducteurs – Fabrication de Détecteurs Semi-conducteurs, Jun 2017, Paris, France. ⟨in2p3-01560811⟩
- G. Brooijmans, M. Dolan, S. Gori, F. Maltoni, M. Mccullough, et al.. Les Houches 2017: Physics at TeV Colliders New Physics Working Group Report. 10th Les Houches Workshop on Physics at TeV Colliders, Jun 2017, Les Houches, France. ⟨hal-01768138⟩
- D. Dauvergne. Prompt-gamma monitoring of particle therapy: state of the art, remaining challenges and future trends . 2nd Jagiellonan Symposium on Fundamental and Applied Subatomic Physics, Jun 2017, Krakow, Poland. ⟨in2p3-01573276⟩
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