Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • M. R. Kibler. Galois rings and Galois fields for physicists. Vth International School on « Symmetry in Integrable Systems and Nuclear Physics », Jul 2017, Tsakhkadzor, Armenia. ⟨hal-02063731⟩
    • L. Massacrier, M. Anselmino, R. Arnaldi, S.J. Brodsky, V. Chambert, et al.. Physics perspectives with AFTER@LHC (A Fixed Target ExpeRiment at LHC). 17th International Conference on Strangeness in Quark Matter, Jul 2017, Utrecht, Netherlands. pp.10001, ⟨10.1051/epjconf/201817110001⟩. ⟨hal-01730124⟩
    • C. Gaillard, Maria Yu Boltoeva, A. Ouadi, ValĂ©rie Mazan, S. Georg, et al.. Ionic liquids for the liquid liquid extraction of uranium(VI). Actinides 2017, Jul 2017, Sendai, Japan. ⟨in2p3-02096449⟩
    • L. Sarrasin, C. Pannetier, N Moncoffre, Y. Pipon, C. Gaillard, et al.. Study of molybdenum and caesium migration in stoichiometric and hyperstoichiometric uranium dioxide. Actinide 2017 conference, Jul 2017, Seidai, Japan. ⟨in2p3-02097455⟩
    • N. Moncoffre, N. Galy, L. Sarrasin, G. Victor, Y. Pipon, et al.. Effects of swift heavy ion irradiation on the structural modifications in nuclear materials. 20th International Conference on Surface Modification of Materials by Ion Beams (SMMIB-2017), Jul 2017, Lisboa, Portugal. ⟨in2p3-02097453⟩
    • Gerald Grenier. Technological Prototypes and Result Highlights of Highly Granular Calorimeters. 2017 European Physical Society Conference on High Energy Physics, Jul 2017, Venice, Italy. pp.497, ⟨10.22323/1.314.0497⟩. ⟨hal-02058335⟩
    • Nicolas Arnaud, Caroline Andreazza, Marie Lauvergeon-Gourdon, Sophie RĂ©my, Fabrice Thalmann, et al.. La Nuit des ondes gravitationnelles : a multi-site outreach event about gravitational waves. The European Physical Society Conference on High Energy Physics (EPS-HEP) 2017, Jul 2017, Venise, Italy. ⟨in2p3-03960089⟩
    • Linda Finco. Search for a new Higgs boson-like low-mass resonance in the diphoton final state at \sqrt{s} = 8 TeV in pp collisions at CMS. 2017 European Physical Society Conference on High Energy Physics, Jul 2017, Venice, Italy. pp.283, ⟨10.22323/1.314.0283⟩. ⟨hal-02058425⟩
    • G. Robbins, F. Mahmoudi, A. Arbey, M. Boudaud. Dark matter and LHC: Complementarities and limitations. 2017 European Physical Society Conference on High Energy Physics, Jul 2017, Venice, Italy. pp.082, ⟨10.22323/1.314.0082⟩. ⟨hal-02058491⟩
    • J. Collot, A. Bes, G. Bosson, S. Curtoni, D. Dauvergne, et al.. Production and characterization of large-size diamond detectors for particle tracking and medical applications. European Physical Society Conference on High Energy Physics (EPS-HEP2017), Jul 2017, Venice, Italy. pp.781. ⟨hal-01680951⟩

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