Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • J. Gascon. Low-mass WIMP Searches with EDELWEISS. 15th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2017), Jul 2017, Sudbury, Canada. ⟨hal-02060130⟩
    • M. Gouzevitch. "H and HH non−resonant prospects for run−3. Higgs Hunting, Jul 2017, Orsay, France. ⟨hal-02076945⟩
    • W. Rau, G. Gerbier, P. Camus, K. Dering, A. Cazes, et al.. CUTE - A Cryogenic Underground Test Facility at SNOLAB. 15th International Conference on Topics in Astroparticle and Underground Physics, Jul 2017, Sudbury, Canada. pp.012128, ⟨10.1088/1742-6596/1342/1/012128⟩. ⟨hal-02467219⟩
    • D. Pagano, S. Aghion, C. Amsler, G. Bonomi, R.S. Brusa, et al.. Gravity and antimatter: the AEgIS experiment at CERN. 15th International Conference on Topics in Astroparticle and Underground Physics, Jul 2017, Sudbury, Canada. pp.012016, ⟨10.1088/1742-6596/1342/1/012016⟩. ⟨hal-02467339⟩
    • C. Augier. Low-Mass WIMP Search with the EDELWEISS Experiment. 13th Rencontres du Vietnam : Exploring the Dark Universe, Jul 2017, Quy Nhon, Vietnam. ⟨hal-02060141⟩
    • Guillaume Maquart. Transition de forme Ă  haut spin dans le noyau octupolaire de thorium 223 et autres aspects mĂ©thodologiques de la spectroscopie gamma moderne. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© de Lyon, 2017. Français. ⟨NNT : 2017LYSE1135⟩. ⟨tel-01684908⟩
    • N. Bastidon, J. Billard, E. Figueroa-Feliciano, S. Heine, Z. Hong, et al.. Optimizing Thermal Detectors for Low-Threshold Applications in Neutrino and Dark Matter Experiments. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.1206-1213, ⟨10.1007/s10909-018-2073-2⟩. ⟨hal-01959933⟩
    • Ph. Camus, A. Cazes, A. Dastgheibi-Fard, K. Dering, G. Gerbier, et al.. CUTE: A Low Background Facility for Testing Cryogenic Dark Matter Detectors. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.813-818, ⟨10.1007/s10909-018-2014-0⟩. ⟨hal-01959936⟩
    • R. Maisonobe, J. Billard, M. Jesus, L. Dumoulin, A. Juillard, et al.. Experimental study and modeling cryogenic detectors decoupling within dry cryostat. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.819-826, ⟨10.1007/s10909-018-2045-6⟩. ⟨hal-01959930⟩
    • R. Maisonobe. Status and Prospects of the EDELWEISS-III Direct WIMP Search Experiment. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.1129-1136, ⟨10.1007/s10909-018-1921-4⟩. ⟨hal-01959935⟩

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