Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Guillaume Maquart. Transition de forme Ă  haut spin dans le noyau octupolaire de thorium 223 et autres aspects mĂ©thodologiques de la spectroscopie gamma moderne. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© de Lyon, 2017. Français. ⟨NNT : 2017LYSE1135⟩. ⟨tel-01684908⟩
  • Ph. Camus, A. Cazes, A. Dastgheibi-Fard, K. Dering, G. Gerbier, et al.. CUTE: A Low Background Facility for Testing Cryogenic Dark Matter Detectors. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.813-818, ⟨10.1007/s10909-018-2014-0⟩. ⟨hal-01959936⟩
  • N. Bastidon, J. Billard, E. Figueroa-Feliciano, S. Heine, Z. Hong, et al.. Optimizing Thermal Detectors for Low-Threshold Applications in Neutrino and Dark Matter Experiments. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.1206-1213, ⟨10.1007/s10909-018-2073-2⟩. ⟨hal-01959933⟩
  • R. Maisonobe. Status and Prospects of the EDELWEISS-III Direct WIMP Search Experiment. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.1129-1136, ⟨10.1007/s10909-018-1921-4⟩. ⟨hal-01959935⟩
  • R. Maisonobe, J. Billard, M. Jesus, L. Dumoulin, A. Juillard, et al.. Experimental study and modeling cryogenic detectors decoupling within dry cryostat. 17th International Workshop on Low Temperature Detectors, Jul 2017, Kurume, Japan. pp.819-826, ⟨10.1007/s10909-018-2045-6⟩. ⟨hal-01959930⟩
  • M. R. Kibler. Galois rings and Galois fields for physicists. Vth International School on « Symmetry in Integrable Systems and Nuclear Physics », Jul 2017, Tsakhkadzor, Armenia. ⟨hal-02063731⟩
  • L. Massacrier, M. Anselmino, R. Arnaldi, S.J. Brodsky, V. Chambert, et al.. Physics perspectives with AFTER@LHC (A Fixed Target ExpeRiment at LHC). 17th International Conference on Strangeness in Quark Matter, Jul 2017, Utrecht, Netherlands. pp.10001, ⟨10.1051/epjconf/201817110001⟩. ⟨hal-01730124⟩
  • C. Gaillard, Maria Yu Boltoeva, A. Ouadi, ValĂ©rie Mazan, S. Georg, et al.. Ionic liquids for the liquid liquid extraction of uranium(VI). Actinides 2017, Jul 2017, Sendai, Japan. ⟨in2p3-02096449⟩
  • L. Sarrasin, C. Pannetier, N Moncoffre, Y. Pipon, C. Gaillard, et al.. Study of molybdenum and caesium migration in stoichiometric and hyperstoichiometric uranium dioxide. Actinide 2017 conference, Jul 2017, Seidai, Japan. ⟨in2p3-02097455⟩
  • N. Moncoffre, N. Galy, L. Sarrasin, G. Victor, Y. Pipon, et al.. Effects of swift heavy ion irradiation on the structural modifications in nuclear materials. 20th International Conference on Surface Modification of Materials by Ion Beams (SMMIB-2017), Jul 2017, Lisboa, Portugal. ⟨in2p3-02097453⟩

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