Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Rosas-Carbajal, K. Jourde, Jean de Bremond d'Ars, B. Carlus, Dominique Gibert, et al.. Three-dimensional density structure of La Soufrière de Guadeloupe lava dome from simultaneous muon radiographies and gravity data. IAVCEI 2017 Scientific Assembly, Aug 2017, Portland, United States. ⟨hal-02087418⟩
  • Anne-Sophie Wozny, Marie-Thérèse Aloy, Gersende Alphonse, Nicolas Magné, Marc Janier, et al.. Gadolinium-based nanoparticles as sensitizing agents to carbon ions in head and neck tumor cells. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13 (8), pp.2655-2660. ⟨10.1016/j.nano.2017.07.015⟩. ⟨hal-01610099⟩
  • Nils Krah, Ilaria Rinaldi. Comparing the Performance of Different Types of Proton Imaging Set-Ups Following a Newly Derived Expression for the Most Likely Path. AAPM 59th annual meeting and exhibition, Jul 2017, Denver, United States. 2017. ⟨hal-01714486⟩
  • Nils Krah, L. de Marzi, Annalisa Patriarca, G. Pitta, Ilaria Rinaldi. High Resolution Proton Radiography Using Sophisticated Image Processing Methods and a Commercial Plug and Play Detector. AAPM 59th Annual Meeting and Exhibition, Jul 2017, Denver, United States. ⟨hal-01795464⟩
  • J. Gascon. Low-mass WIMP searches with the EDELWEISS experiment. 15th International Conference on Topics in Astroparticle and Underground Physics, Jul 2017, Sudbury, Canada. pp.012064, ⟨10.1088/1742-6596/1342/1/012064⟩. ⟨hal-02467333⟩
  • M. Gouzevitch. "H and HH non−resonant prospects for run−3. Higgs Hunting, Jul 2017, Orsay, France. ⟨hal-02076945⟩
  • W. Rau, G. Gerbier, P. Camus, K. Dering, A. Cazes, et al.. CUTE - A Cryogenic Underground Test Facility at SNOLAB. 15th International Conference on Topics in Astroparticle and Underground Physics, Jul 2017, Sudbury, Canada. pp.012128, ⟨10.1088/1742-6596/1342/1/012128⟩. ⟨hal-02467219⟩
  • J. Gascon. Low-mass WIMP Searches with EDELWEISS. 15th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2017), Jul 2017, Sudbury, Canada. ⟨hal-02060130⟩
  • D. Pagano, S. Aghion, C. Amsler, G. Bonomi, R.S. Brusa, et al.. Gravity and antimatter: the AEgIS experiment at CERN. 15th International Conference on Topics in Astroparticle and Underground Physics, Jul 2017, Sudbury, Canada. pp.012016, ⟨10.1088/1742-6596/1342/1/012016⟩. ⟨hal-02467339⟩
  • C. Augier. Low-Mass WIMP Search with the EDELWEISS Experiment. 13th Rencontres du Vietnam : Exploring the Dark Universe, Jul 2017, Quy Nhon, Vietnam. ⟨hal-02060141⟩

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