Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • W. Ryssens, M. Bender, P.-H. Heenen. Towards symmetry-unrestricted Skyrme-HFB in coordinate-space representation: the example of rotational bands of the octupole-deformed nucleus ^{222}Th. 35th Mazurian Lakes Conference on Physics, Sep 2017, Piaski, Poland. pp.339-346, ⟨10.5506/APhysPolB.49.339⟩. ⟨hal-01763843⟩
  • P. Becker, D. Davesne, J. Meyer, J. Navarro, A. Pastore. Skyrme N2LO pseudo-potential for calculations of properties of atomic nuclei. 35th Mazurian Lakes Conference on Physics, Sep 2017, Piaski, Poland. pp.331, ⟨10.5506/APhysPolB.49.331⟩. ⟨hal-01763852⟩
  • Farvah Mahmoudi, Tobias Hurth, Siavash Neshatpour. Implications of flavour anomalies for new physics. 17th Hellenic School and Workshops on Elementary Particle Physics and Gravity, Sep 2017, Corfu, Greece. pp.038, ⟨10.22323/1.318.0038⟩. ⟨hal-01871991⟩
  • E. Bernichon, A. Vallard, Qiang Wang, Valéry Attignon, Daniel Pissaloux, et al.. Genomic alterations and radioresistance in breast cancer: an analysis of the ProfiLER protocol.. Annals of Oncology, 2017, 28 (11), pp.2773-2779. ⟨10.1093/annonc/mdx488⟩. ⟨hal-01610114⟩
  • J. Vijande, A. Valcarce, J.M. Richard. Breaking Symmetry Effects on Heavy Tetraquarks. 21st International Conference on Particles and Nuclei, Sep 2017, Beijing, China. pp.1860036, ⟨10.1142/S2010194518600364⟩. ⟨hal-01797128⟩
  • M. Gouzevitch. Prospects for Higgs Physics at HL−LHC. 2nd CMS Workshop «Perspectives on Physics and on CMS at HL−LHC, Sep 2017, Vana, Bulgaria. ⟨hal-02076966⟩
  • Nicolas Chanon. Matrix Element Method for kinematic fitting. Matrix Element Method for LHC 2017, Aug 2017, Berlin, Germany. ⟨hal-02052686⟩
  • G. Consolati, S. Aghion, C. Amsler, G. Bonomi, R.S. Brusa, et al.. Positronium for Antihydrogen Production in the AEGIS Experiment. 12th International Workshop on Positron and Positronium Chemistry, Aug 2017, Lublin, Poland. pp.1443-1449, ⟨10.12693/APhysPolA.132.1443⟩. ⟨hal-01669699⟩
  • C. Evans, S. Aghion, C. Amsler, G. Bonomi, R.S. Brusa, et al.. Towards the first measurement of matter-antimatter gravitational interaction. 6th International Conference on New Frontiers in Physics, Aug 2017, Kolymbari, Greece. pp.02040, ⟨10.1051/epjconf/201818202040⟩. ⟨hal-01965297⟩
  • Jacques Marteau, Marina Rosas-Carbajal, Kevin Jourde, Jean de Bremond d'Ars, Bruno Carlus, et al.. Monitoring the La Soufrière de Guadeloupe hydrothermal system with a regularly-spaced muon telescope network. IAVCEI 2017 scientific Assembly, Aug 2017, Portland, Oregon, United States. pp.649, 2017, Abstract book. Fostering Integrative Studies of Volcanoes. ⟨insu-01718421⟩

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