Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J.-B. Guy, S. Espenel, A. Vallard, B. MĂ©ry, C. Rancoule, et al.. Targeting Cancer Stem Cells in HNSCC: Synergic Effect of Cetuximab and ABT-199 in Combination with Photon Radiation. ASTRO Meeting, Sep 2017, San Diego, United States. 99 (2), 2017, International Journal of Radiation Oncology*Biology*Physics - Proceedings of the American Society for Radiation Oncology. ⟨10.1016/j.ijrobp.2017.06.2028⟩. ⟨hal-01610138⟩
  • A. Vallard, E. Bernichon, Wang Q., ValĂ©ry Attignon, Daniel Pissaloux, et al.. Genomic Alterations and Radioresistance in Breast Cancer: An Analysis of the Profiler Protocol. ASTRO Meeting, Sep 2017, San Diego, United States. pp.S52, ⟨10.1016/j.ijrobp.2017.06.132⟩. ⟨hal-01610147⟩
  • R. Meissner, A. Ribar, K. Fink, S. Huber, M. Probst, et al.. Interactions of secondary electrons with imidazole compounds. 9th Ă–GMBT Annual Meeting & 8th Life Science Meeting, Sep 2017, Innsbruck, Austria. ⟨in2p3-02087335⟩
  • M. Trimarchi, S. Pirrone, G. Politi, B. Gnoffo, J.P. Wieleczko, et al.. Study of the ^{78,86}Kr+^{40,48}Ca Reactions at 10 A MeV: Comparison with Theoretical Models. 24th Nuclear Physics Workshop “Marie and Pierre Curie”, Sep 2017, Kazimierz Dolny, Poland. pp.189, ⟨10.5506/APhysPolBSupp.11.189⟩. ⟨hal-01792301⟩
  • X. Artru, M.-C. Artru. Different focalisations of Optical Transition Radiation and Diffraction Radiation. 12th International Symposium Radiation from Relativistic Electrons in Periodic Structures, Sep 2017, Hamburg, Germany. pp.C04025-C04025, ⟨10.1088/1748-0221/13/04/C04025⟩. ⟨hal-01862026⟩
  • Pierre Becker. DĂ©veloppement d'une interaction nuclĂ©aire effective de nouvelle gĂ©nĂ©ration. Physique NuclĂ©aire ThĂ©orique [nucl-th]. UniversitĂ© de Lyon, 2017. Français. ⟨NNT : 2017LYSE1153⟩. ⟨tel-01699441⟩
  • F. Guatieri, S. Aghion, C. Amsler, G. Angela, G. Bonomi, et al.. AE\overline{g}IS latest results. 6th International Conference on Exotic Atoms and Related Topics, Sep 2017, Vienna, Austria. pp.01037, ⟨10.1051/epjconf/201718101037⟩. ⟨hal-03830376⟩
  • Giacomo Fedi, Fabrizio Palla, Christos Gentsos, Daniel Magalotti, Atanu Modak, et al.. A Real-Time Demonstrator for Track Reconstruction in the CMS L1 Track-Trigger System Based on Custom Associative Memories and High-Performance FPGAs. Topical Workshop on Electronics for Particle Physics, Sep 2017, Santa Cruz, United States. pp.138, ⟨10.22323/1.313.0138⟩. ⟨hal-02059110⟩
  • Xiushan Chen, Denis Dauvergne, Etienne Testa, Guo-Neng Lu, Luigi Caponetto, et al.. Data Acquisition Board for a Beam-Tagging Hodoscope Used in Hadrontherapy Monitoring. TWEPP 2017 Topical Workshop on Electronics for Particle Physics, Sep 2017, Santa Cruz, United States. 2017. ⟨hal-01731367⟩
  • O. StĂ©zowski. Data Analysis: Overview and status update. 18th AGATA Week, Sep 2017, Milan, Italy. ⟨in2p3-02101717⟩

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