Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Floriane Poignant, Benoit Gervais, Andrei Ipatov, Caterina Monini, Micaela Cunha, et al.. Biophysical modelisation of gold nanoparticles radiosensitizing effects. International Conference on Monte Carlo Techniques for Medical Applications (MCMA2017), Oct 2017, Napoli, Italy. pp.38-39, ⟨10.1016/j.ejmp.2017.09.094⟩. ⟨hal-01620547⟩
    • Sophie Espenel, Jean-Baptiste Guy, Anne-Sophie Wozny, Priscillia Battiston-Montagne, ChloĂ© Rancoule, et al.. Evaluation prĂ©clinique en modèle 3D de l’association de l’ABT-199 au cetuximab et aux radiations ionisantes sur les cellules cancĂ©reuses ORL. SFRO 17, Oct 2017, Paris, France. ⟨hal-02062295⟩
    • Pierre Lansonneur. MoirĂ© Deflectometry with a Low-Energy Ion Beam for the AEGIS Experiment. Nuclear Experiment [nucl-ex]. UniversitĂ© de Lyon, 2017. English. ⟨NNT : 2017LYSE1191⟩. ⟨tel-01674237⟩
    • N. Galy, N. Toulhoat, N. Moncoffre, Y. Pipon, N. BĂ©rerd, et al.. Ion irradiation to simulate neutron irradiation in model graphites: Consequences for nuclear graphite. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017, 409, pp.235 - 240. ⟨10.1016/j.nimb.2017.05.056⟩. ⟨hal-01626204⟩
    • Veronica Tessaro, Mariel E. Galassi, Benoit Gervais, Michael Beuve. EvaluaciĂłn de la contribucion de electrones Auger y efectos relativistas en la determinaciĂłn de valores-w por impacto de electrones. 102a ReuniĂłn Nacional de FĂ­sica - AsociaciĂłn FĂ­sica Argentina, Sep 2017, Buenos Aires, Argentina. ⟨hal-02050659⟩
    • A. Vallard, E. Bernichon, Wang Q., ValĂ©ry Attignon, Daniel Pissaloux, et al.. Genomic Alterations and Radioresistance in Breast Cancer: An Analysis of the Profiler Protocol. ASTRO Meeting, Sep 2017, San Diego, United States. pp.S52, ⟨10.1016/j.ijrobp.2017.06.132⟩. ⟨hal-01610147⟩
    • R. Meissner, A. Ribar, K. Fink, S. Huber, M. Probst, et al.. Interactions of secondary electrons with imidazole compounds. 9th Ă–GMBT Annual Meeting & 8th Life Science Meeting, Sep 2017, Innsbruck, Austria. ⟨in2p3-02087335⟩
    • J.-B. Guy, S. Espenel, A. Vallard, B. MĂ©ry, C. Rancoule, et al.. Targeting Cancer Stem Cells in HNSCC: Synergic Effect of Cetuximab and ABT-199 in Combination with Photon Radiation. ASTRO Meeting, Sep 2017, San Diego, United States. 99 (2), 2017, International Journal of Radiation Oncology*Biology*Physics - Proceedings of the American Society for Radiation Oncology. ⟨10.1016/j.ijrobp.2017.06.2028⟩. ⟨hal-01610138⟩
    • M. Trimarchi, S. Pirrone, G. Politi, B. Gnoffo, J.P. Wieleczko, et al.. Study of the ^{78,86}Kr+^{40,48}Ca Reactions at 10 A MeV: Comparison with Theoretical Models. 24th Nuclear Physics Workshop “Marie and Pierre Curie”, Sep 2017, Kazimierz Dolny, Poland. pp.189, ⟨10.5506/APhysPolBSupp.11.189⟩. ⟨hal-01792301⟩
    • Pierre Becker. DĂ©veloppement d'une interaction nuclĂ©aire effective de nouvelle gĂ©nĂ©ration. Physique NuclĂ©aire ThĂ©orique [nucl-th]. UniversitĂ© de Lyon, 2017. Français. ⟨NNT : 2017LYSE1153⟩. ⟨tel-01699441⟩

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