Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Verónica Belén Tessaro, Benoit Gervais, Floriane Poignant, Michael Beuve, Mariel Elisa Galassi. Monte Carlo transport of swift protons and light ions in water: The influence of excitation cross sections, relativistic effects, and Auger electron emission in w-values. Phys.Medica, 2021, 88, pp.71-85. ⟨10.1016/j.ejmp.2021.06.006⟩. ⟨hal-03335777⟩
    • Janina Kopyra, Franck Rabilloud, Paulina Wierzbicka, Hassan Abdoul-Carime. Energy-Selective Decomposition of Organometallic Compounds by Slow Electrons: The Case of Chloro(dimethyl sulfide)gold(I). Journal of Physical Chemistry A, 2021, 125 (4), pp.966-972. ⟨10.1021/acs.jpca.0c09988⟩. ⟨hal-03148189⟩
    • David Sarrut, A. Etxebeste, Nils Krah, Jean Michel Létang. Modeling complex particles phase space with GAN for Monte Carlo SPECT simulations: a proof of concept. Physics in Medicine and Biology, 2021, 66 (5), pp.055014. ⟨10.1088/1361-6560/abde9a⟩. ⟨hal-03150535⟩
    • X. Liu, B. Cederwall, C. Qi, R.A. Wyss, Ö. Aktas, et al.. Evidence for enhanced neutron-proton correlations from the level structure of the N=Z+1 nucleus _{43}^{87}\mathrm{Tc}_{44}. Physical Review C, 2021, 104 (2), pp.L021302. ⟨10.1103/PhysRevC.104.L021302⟩. ⟨hal-03335724⟩
    • Sébastien Curtoni, Marie-Laure Gallin-Martel, Latifa Abbassi, Alexandre Bes, Germain Bosson, et al.. Performance of CVD diamond detectors for single ion beam-tagging applications in hadrontherapy monitoring. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2021, 1015, pp.165757. ⟨10.1016/j.nima.2021.165757⟩. ⟨hal-03227464⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Measurement of differential cross sections for Z bosons produced in association with charm jets in pp collisions at \sqrt{s} = 13 TeV. JHEP, 2021, 04, pp.109. ⟨10.1007/JHEP04(2021)109⟩. ⟨hal-03098853⟩
    • Dietrich Averbeck, Claire Rodriguez-Lafrasse. Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts. Int.J.Mol.Sci., 2021, 22 (20), pp.11047. ⟨10.3390/ijms222011047⟩. ⟨hal-03450000⟩
    • Alexandra Carvalho, Florian Goertz, Ken Mimasu, Maxime Gouzevitch, Anamika Aggarwal. On the reinterpretation of non-resonant searches for Higgs boson pairs. Journal of High Energy Physics, 2021, 02, pp.049. ⟨10.1007/JHEP02(2021)049⟩. ⟨hal-02410842⟩
    • Benjamin Bally, Michael Bender. Projection on particle number and angular momentum: Example of triaxial Bogoliubov quasiparticle states. Physical Review C, 2021, 103 (2), pp.024315. ⟨10.1103/PhysRevC.103.024315⟩. ⟨hal-03010992⟩
    • B.P. Abbott, R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, et al.. A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo. Astrophys.J., 2021, 909 (2), pp.218. ⟨10.3847/1538-4357/abdcb7⟩. ⟨hal-02303025⟩

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