Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • F. Poignant, A. Ipatov, O. Chakchir, P.J. Lartaud, É. Testa, et al.. Theoretical derivation and benchmarking of cross sections for low-energy electron transport in gold. The European Physical Journal Plus, 2020, 135 (4), pp.358. ⟨10.1140/epjp/s13360-020-00354-3⟩. ⟨hal-02550038⟩
  • A. Etxebeste, D. Dauvergne, M. Fontana, J.M. Létang, G. Llosá, et al.. CCMod: a GATE module for Compton camera imaging simulation. Physics in Medicine and Biology, 2020, 65 (5), pp.055004. ⟨10.1088/1361-6560/ab6529⟩. ⟨hal-02497878⟩
  • Feriel Khellaf, Nils Krah, Jean-Michel Létang, Charles-Antoine Collins-Fekete, Simon Rit. A comparison of direct reconstruction algorithms in proton computed tomography. Physics in Medicine and Biology, 2020, 65 (10), pp.105010. ⟨10.1088/1361-6560/ab7d53⟩. ⟨hal-02502179⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, et al.. Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells. Scientific Reports, 2020, 10 (1), pp.21357. ⟨10.1038/s41598-020-78354-7⟩. ⟨hal-03070648⟩
  • Caterina Monini, Micaela Cunha, Laurie Chollier, Etienne Testa, Michael Beuve. Determination of the Effective Local Lethal Function for the NanOx Model. Rad.Res., 2020, 193 (4), pp.331-340. ⟨10.1667/rr15463.1⟩. ⟨hal-02571523⟩
  • Chen-Hui Chan, Floriane Poignant, Michael Beuve, Elise Dumont, David Loffreda. Effect of the Ligand Binding Strength on the Morphology of Functionalized Gold Nanoparticles. Journal of Physical Chemistry Letters, 2020, pp.2717-2723. ⟨10.1021/acs.jpclett.0c00300⟩. ⟨hal-02519412⟩
  • Denis Dauvergne, Oreste Allegrini, Cairo Caplan, Xiushan Chen, Sébastien Curtoni, et al.. On the role of single particle irradiation and fast timing for efficient online-control in particle therapy. Frontiers in Physics, 2020, 8, pp.567215. ⟨10.3389/fphy.2020.567215⟩. ⟨hal-02939215⟩
  • Elisabeth Daguenet, Safa Louati, Anne-Sophie Wozny, Nicolas Vial, Mathilde Gras, et al.. Radiation-induced bystander and abscopal effects: important lessons from preclinical models. British Journal of Cancer, 2020, 123 (3), pp.339-348. ⟨10.1038/s41416-020-0942-3⟩. ⟨hal-02927729⟩
  • Nicolas Magné, Renaud Sabatier, Marie Wislez, Thierry André, Manuel Rodrigues, et al.. Florilège des actualités oncologiques internationales en 2019. Bulletin du Cancer, 2020, 107 (2), pp.148-156. ⟨10.1016/j.bulcan.2020.01.010⟩. ⟨hal-02518020⟩
  • J. Kopyra, Franck Rabilloud, Hassan Abdoul-Carime. Core-excited resonances initiated by unusually low energy electrons observed in dissociative electron attachment to Ni(II) (bis)acetylacetonate. J.Chem.Phys., 2020, 153 (12), pp.124302. ⟨10.1063/5.0023716⟩. ⟨hal-02955777⟩

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