Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • M. Gouzevitch. Recent LHC results from ATLAS and CMS, prospects for High Lumi LHC. 2017 International Workshop on Future Linear Colliders (LCWS2017), Oct 2017, Strasbourg, France. ⟨hal-02076972⟩
    • Mattia Fontana, Denis Dauvergne, Jochen Krimmer, Jean Michel Létang, Jean-Luc Ley, et al.. Comparison between Anger and Compton cameras for medical imaging: a Monte Carlo simulation study. 2017 IEEE NSS/MIC/RTSD, Oct 2017, Atlanta, United States. 2017. ⟨hal-01609932⟩
    • Nils Krah, Mattia Fontana, Ilaria Rinaldi. Comparative study of the performance of proton imaging set-ups in terms of spatial resolution. 2017 IEEE NSS/MIC/RTSD, Oct 2017, Atlanta, United States. 2017. ⟨hal-01795560⟩
    • A. Irles, C. Chavez-Barajas, T. Coates, F. Salvatore, D. Cussans, et al.. DQM4HEP - A Generic Online Monitor for Particle Physics Experiments. 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2017, Atlanta, United States. ⟨10.1109/NSSMIC.2017.8532593⟩. ⟨hal-01703576⟩
    • X. Chen, B. Carlus, C. Caplan, L. Caponetto, J.P. Cachemiche, et al.. A Data Acquisition System for a Beam-Tagging Hodoscope used in Hadrontherapy Monitoring. 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2017, Atlanta, United States. ⟨10.1109/NSSMIC.2017.8532646⟩. ⟨hal-02097393⟩
    • François Lagarde. Caractérisation de détecteurs à plaques résistives de verres de basse résistivité en vue de la mise à niveau de CMS. Physique des accélérateurs [physics.acc-ph]. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSE1217⟩. ⟨tel-01736264⟩
    • Cynthia Hadjidakis, M. Anselmino, R. Arnaldi, S.J. Brodsky, V. Chambert, et al.. Physics opportunities with a fixed target experiment at the LHC (AFTER@LHC). 17th International Workshop on Polarized Sources, Targets, and Polarimetry, Oct 2017, Kaist, South Korea. pp.035, ⟨10.22323/1.324.0035⟩. ⟨hal-01833751⟩
    • Vianney Motte, Thierry Sauvage, Hervé Lecoq, Didier Gosset, G. Gutierrez, et al.. Helium diffusion and cluster nucleation in implanted B_4C boron carbide. Ion Beam Analysis Conference, Oct 2017, Shangai, China. ⟨in2p3-02097454⟩
    • Anne-Sophie Wozny, Gersende Alphonse, Yannick Saintigny, Michaël Beuve, Claire Rodriguez-Lafrasse. A major contribution of the HIF-1α pathway in the oxygen effect. 63rd annual international meeting of Radiation Reaserach Society, Oct 2017, Cancun, Mexico. 2017. ⟨hal-01610972⟩
    • Claire Rodriguez-Lafrasse, Marie-Thérèse Aloy, Jacqueline Sidi Boumedine, Shady Kotb, Lucie Sancey, et al.. AGuIX radiosensitizing nanoparticles: from molecular events to clinical applications. 63rd annual international meeting of Radiation Reaserach Society, Oct 2017, Cancun, Mexico. ⟨hal-01610963⟩

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