Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Autiero. Dual−phase electronics. Far Detector DAQ Design Workshop, Oct 2017, Columbia, New York, United States. ⟨in2p3-02108212⟩
  • Matthieu Giroux, Hamid Ladjal, Philippe Giraud, Michael Beuve, Shariat Behzad. Patient-Specific Biomechanical Modeling of the Lung Tumor for Radiation Therapy. Computer Methods in Biomechanics and Biomedical Engineering, 2017, 20 (sup1), pp.95 - 96. ⟨10.1080/10255842.2017.1382878⟩. ⟨hal-01628725⟩
  • A. Pulcini, E. Vardaci, E. Kozulin, M. Ashaduzzaman, C. Borcea, et al.. Gamma rays as probe of fission and quasi-fission dynamics in the reaction ^{32}S + ^{197}Au near the Coulomb barrier. International Workshop Nuclear Reactions on Nucleons and Nuclei, Oct 2017, Melissa, Italy. pp.012013, ⟨10.1088/1742-6596/1014/1/012013⟩. ⟨hal-01839681⟩
  • M. Gouzevitch. Recent LHC results from ATLAS and CMS, prospects for High Lumi LHC. 2017 International Workshop on Future Linear Colliders (LCWS2017), Oct 2017, Strasbourg, France. ⟨hal-02076972⟩
  • Sijing Zhang. Low-mass scalar searches in CMS. International Workshop on Future Linear Colliders (LCWS 2017), Oct 2017, Strasbourg, France. ⟨hal-02071365⟩
  • Paul Bertier. Study of solvated molecular ion stability in the gas-phase : cooling and irradiation. Nuclear Experiment [nucl-ex]. Université de Lyon, 2017. English. ⟨NNT : 2017LYSE1207⟩. ⟨tel-01710261⟩
  • Mattia Fontana, Denis Dauvergne, Jochen Krimmer, Jean Michel Létang, Jean-Luc Ley, et al.. Comparison between Anger and Compton cameras for medical imaging: a Monte Carlo simulation study. 2017 IEEE NSS/MIC/RTSD, Oct 2017, Atlanta, United States. 2017. ⟨hal-01609932⟩
  • Nils Krah, Mattia Fontana, Ilaria Rinaldi. Comparative study of the performance of proton imaging set-ups in terms of spatial resolution. 2017 IEEE NSS/MIC/RTSD, Oct 2017, Atlanta, United States. 2017. ⟨hal-01795560⟩
  • A. Irles, C. Chavez-Barajas, T. Coates, F. Salvatore, D. Cussans, et al.. DQM4HEP - A Generic Online Monitor for Particle Physics Experiments. 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2017, Atlanta, United States. ⟨10.1109/NSSMIC.2017.8532593⟩. ⟨hal-01703576⟩
  • X. Chen, B. Carlus, C. Caplan, L. Caponetto, J.P. Cachemiche, et al.. A Data Acquisition System for a Beam-Tagging Hodoscope used in Hadrontherapy Monitoring. 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2017, Atlanta, United States. ⟨10.1109/NSSMIC.2017.8532646⟩. ⟨hal-02097393⟩

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