Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Caterina Monini, Etienne Testa, Michael Beuve. NanOx , un nouveau modèle multi-Ă©chelle pour prĂ©dire l’EBR des ions en hadronthĂ©rapie. SIRLAF: 13ème Congrès Francophone de Radiobiologie, Dec 2017, Lyon, France. ⟨hal-01731420⟩
  • Floriane Poignant, Benoit Gervais, Andrei Ipatov, Hela Charfi, Caterina Monini, et al.. ModĂ©lisation biophysique de l’effet radiosensibilisant des nanoparticles Ă  Ă©lĂ©ment lourd. SIRLAF: 13ème Congrès Francophone de Radiobiologie, Dec 2017, Lyon, France. ⟨hal-01731451⟩
  • Alexandra Lauret, CĂ©line MalĂ©sys, Jonathan Lopez, Pierre Philouze, Philippe CĂ©ruse, et al.. Cellules Tumorales Circulantes : biomarqueurs prĂ©dictifs de l’échappement tumoral Ă  la radio(chimio)thĂ©rapie dans les cancers des VADS ?. SIRLAF: 13ème Congrès Francophone de Radiobiologie, Dec 2017, Lyon, France. ⟨hal-01738727⟩
  • L. Sarrasin, C. Gaillard, Y. Pipon, N. Moncoffre, P. Simon. Effect of stoichiometry on UO_2 behavior under high temperature and irradiation. AnO2-Raman2017: 2nd Workshop on Raman spectroscopy in actinide oxides, Dec 2017, OrlĂ©ans, France. ⟨in2p3-02097458⟩
  • Jean-Baptiste Guy, BenoĂ®te MĂ©ry, Edouard Ollier, Sophie Espenel, Alexis Vallard, et al.. Dual “mAb” HER family blockade in head and neck cancer human cell lines combined with photon therapy. Scientific Reports, 2017, 7 (1), pp.12207 - 12207. ⟨10.1038/s41598-017-12367-7⟩. ⟨hal-01609975⟩
  • Clotilde Gaillard, C. Pannetier, L. Sarrasin, Y. Pipon, N Moncoffre, et al.. Etude de la migration des produits de fission (Mo, Cs) dans le combustible UO_2 : effet de la tempĂ©rature, de l'irradiation et de l'oxydation. JournĂ©e de la Division de Chimie Physique (SCF/SCP), Nov 2017, Paris, France. ⟨in2p3-02095584⟩
  • Olga Komova, Eugene Krasavin, Elena Nasonova, Larisa Mel’nikova, Nina Shmakova, et al.. Relationship between radioadaptive response and individual radiosensitivity to low doses of gamma radiation: an extended study of chromosome damage in blood lymphocytes of three donors. International Journal of Radiation Biology, 2017, 94 (1), pp.54 - 61. ⟨10.1080/09553002.2018.1399226⟩. ⟨hal-01685496⟩
  • D. Dauvergne, A. Bès, G. Bosson, J. Collot, S. Curtoni, et al.. Large area diamond detectors for fast beam tagging applications in particle therapy Motivation (1/5) Need for in vivo ballistic control in particle therapy. 6th ADAMAS Workshop, Nov 2017, Zagreb, Croatia. ⟨hal-01726351⟩
  • GaĂ«l Touquet. Recherche de bosons de Higgs supplĂ©mentaires dans le cadre des thĂ©ories 2HDM par l'observation de dĂ©sintĂ©gration H->tau tau dans l’expĂ©rience CMS du LHC. JournĂ©es de Rencontre des Jeunes Chercheurs 2017, Nov 2017, La Pommeraye, France. ⟨hal-02070545⟩
  • Boris Teyssier. Étude de la production de mĂ©son neutre lĂ©ger dans la voie de dĂ©sintĂ©gration dimuonique en collision proton-proton Ă  sqrt(s) = 13 TeV en rapiditĂ© vers l'avant dans ALICE au LHC du CERN. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© de Lyon, 2017. Français. ⟨NNT : 2017LYSE1240⟩. ⟨tel-01779180⟩

Powered by HAL logo