Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Andreev, A. Baghdasaryan, K. Begzsuren, A. Belousov, A. Bolz, et al.. Determination of electroweak parameters in polarised deep-inelastic scattering at HERA. Eur.Phys.J.C, 2018, 78 (9), pp.777. ⟨10.1140/epjc/s10052-018-6236-8⟩. ⟨hal-01846597⟩
  • Timo Antero Aaltonen, Victor Mukhamedovich Abazov, Braden Keim Abbott, Bannanje Sripath Acharya, Mark Raymond Adams, et al.. Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron. Phys.Rev.Lett., 2018, 120 (4), pp.042001. ⟨10.1103/PhysRevLett.120.042001⟩. ⟨hal-01704669⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for Higgs boson pair production in events with two bottom quarks and two tau leptons in proton–proton collisions at \sqrt s =13TeV. Phys.Lett.B, 2018, 778, pp.101-127. ⟨10.1016/j.physletb.2018.01.001⟩. ⟨hal-01703836⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for supersymmetry in events with one lepton and multiple jets exploiting the angular correlation between the lepton and the missing transverse momentum in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2018, 780, pp.384-409. ⟨10.1016/j.physletb.2018.03.028⟩. ⟨hal-01758790⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the pair production of third-generation squarks with two-body decays to a bottom or charm quark and a neutralino in proton–proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2018, 778, pp.263-291. ⟨10.1016/j.physletb.2018.01.012⟩. ⟨hal-01704945⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for Higgsino pair production in pp collisions at \sqrt{s} = 13 TeV in final states with large missing transverse momentum and two Higgs bosons decaying via H \to b \bar b. Phys.Rev.D, 2018, 97 (3), pp.032007. ⟨10.1103/PhysRevD.97.032007⟩. ⟨hal-01707632⟩
  • A. M. Sirunyan, A. Tumasyan, W. Adam, E. Asilar, T. Bergauer, et al.. Search for vectorlike light-flavor quark partners in proton-proton collisions at \sqrt s =8 TeV. Phys.Rev.D, 2018, 97, pp.072008. ⟨10.1103/PhysRevD.97.072008⟩. ⟨hal-01768074⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of the Higgs boson decay to a pair of \tau leptons with the CMS detector. Phys.Lett.B, 2018, 779, pp.283-316. ⟨10.1016/j.physletb.2018.02.004⟩. ⟨hal-01725007⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for top squarks decaying via four-body or chargino-mediated modes in single-lepton final states in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 09, pp.065. ⟨10.1007/JHEP09(2018)065⟩. ⟨hal-01801947⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a new scalar resonance decaying to a pair of Z bosons in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2018, 06, pp.127. ⟨10.1007/JHEP06(2018)127⟩. ⟨hal-01774085⟩

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