Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • The Cms Collaboration, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, et al.. Search for new physics in top quark production with additional leptons in proton-proton collisions at \sqrt{s} = 13 TeV using effective field theory. Journal of High Energy Physics, 2021, 03, pp.095. ⟨10.1007/JHEP03(2021)095⟩. ⟨hal-03098879⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Correlations of azimuthal anisotropy Fourier harmonics with subevent cumulants in pPb collisions at \sqrt{s_{NN}}=8.16TeV. Physical Review C, 2021, 103 (1), pp.014902. ⟨10.1103/PhysRevC.103.014902⟩. ⟨hal-02154224⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for top squark pair production using dilepton final states in {\text {p}}{\text {p}} collision data collected at \sqrt{s}=13\,\text {TeV}. Eur.Phys.J.C, 2021, 81 (1), pp.3. ⟨10.1140/epjc/s10052-020-08701-5⟩. ⟨hal-02934073⟩
  • Alexandra Carvalho, Florian Goertz, Ken Mimasu, Maxime Gouzevitch, Anamika Aggarwal. On the reinterpretation of non-resonant searches for Higgs boson pairs. Journal of High Energy Physics, 2021, 02, pp.049. ⟨10.1007/JHEP02(2021)049⟩. ⟨hal-02410842⟩
  • Dietrich Averbeck, Claire Rodriguez-Lafrasse. Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts. International Journal of Molecular Sciences, 2021, 22 (20), pp.11047. ⟨10.3390/ijms222011047⟩. ⟨hal-03450000⟩
  • Rachel J. Bruch, Avishay Gal-Yam, Steve Schulze, Ofer Yaron, Yi Yang, et al.. A Large Fraction of Hydrogen-rich Supernova Progenitors Experience Elevated Mass Loss Shortly Prior to Explosion. The Astrophysical Journal, 2021, 912 (1), pp.46. ⟨10.3847/1538-4357/abef05⟩. ⟨hal-02939999⟩
  • Benjamin Bally, Michael Bender. Projection on particle number and angular momentum: Example of triaxial Bogoliubov quasiparticle states. Phys.Rev.C, 2021, 103 (2), pp.024315. ⟨10.1103/PhysRevC.103.024315⟩. ⟨hal-03010992⟩
  • B.P. Abbott, R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, et al.. A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo. Astrophys.J., 2021, 909 (2), pp.218. ⟨10.3847/1538-4357/abdcb7⟩. ⟨hal-02303025⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of differential \mathrm{t\bar{t}} production cross sections using top quarks at large transverse momenta in pp collisions at \sqrt{s} = 13 TeV. Physical Review D, 2021, 103 (5), pp.052008. ⟨10.1103/PhysRevD.103.052008⟩. ⟨hal-02934069⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, et al.. Search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector boson pairs in proton–proton collisions at \sqrt{s} = 13\,{\text {TeV}}. Eur.Phys.J.C, 2021, 81 (8), pp.723. ⟨10.1140/epjc/s10052-021-09472-3⟩. ⟨hal-03210346⟩

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