Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, K. Ackley, et al.. Population Properties of Compact Objects from the Second LIGO-Virgo Gravitational-Wave Transient Catalog. Astrophys.J.Lett., 2021, 913 (1), pp.L7. ⟨10.3847/2041-8213/abe949⟩. ⟨hal-03010977⟩
    • Luis C.N. Santos, Clésio E. Mota, Franciele M. da Silva, Guilherme Grams, I.P. Lobo. Effects of modified dispersion relations on free Fermi gas: Equations of state and applications in astrophysics. Physics Letters B, 2021, 822, pp.136684. ⟨10.1016/j.physletb.2021.136684⟩. ⟨hal-03388134⟩
    • A. Kerbizi, X. Artru, A. Martin. Production of vector mesons in the String+{}^3P_0 model of polarized quark fragmentation. Physical Review D, 2021, 104 (11), pp.114038. ⟨10.1103/PhysRevD.104.114038⟩. ⟨hal-03355319⟩
    • Alexandre Arbey, Jérémy Auffinger, Marc Geiller, Etera R. Livine, Francesco Sartini. Hawking radiation by spherically-symmetric static black holes for all spins. II. Numerical emission rates, analytical limits, and new constraints. Physical Review D, 2021, 104 (8), pp.084016. ⟨10.1103/PhysRevD.104.084016⟩. ⟨hal-03287550⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Production of light-flavor hadrons in pp collisions at \sqrt{s}~=~7\text { and }\sqrt{s} = 13 \, \text { TeV}. Eur.Phys.J.C, 2021, 81 (3), pp.256. ⟨10.1140/epjc/s10052-020-08690-5⟩. ⟨hal-02863123⟩
    • Mamadou Soumboundou, Julien Dossou, Yossef Kalaga, Innocent Nkengurutse, Ibrahima Faye, et al.. Is Response to Genotoxic Stress Similar in Populations of African and European Ancestry? A Study of Dose-Response After in vitro Irradiation. Frontiers in Genetics, 2021, 12, pp.657999. ⟨10.3389/fgene.2021.657999⟩. ⟨hal-03472634⟩
    • Maxime Jacquet, Sara Marcatili, Marie-Laure Gallin-Martel, Jean-Luc Bouly, Yannick Boursier, et al.. A time-of-flight-based reconstruction for real-time prompt-gamma imaging in proton therapy. Physics in Medicine and Biology, 2021, 66 (13), pp.135003. ⟨10.1088/1361-6560/ac03ca⟩. ⟨hal-03319261⟩
    • B. Abi, R. Acciarri, M.A. Acero, G. Adamov, D. Adams, et al.. Supernova neutrino burst detection with the Deep Underground Neutrino Experiment. Eur.Phys.J.C, 2021, 81 (5), pp.423. ⟨10.1140/epjc/s10052-021-09166-w⟩. ⟨hal-02934048⟩
    • Alexandra Carvalho, Florian Goertz, Ken Mimasu, Maxime Gouzevitch, Anamika Aggarwal. On the reinterpretation of non-resonant searches for Higgs boson pairs. Journal of High Energy Physics, 2021, 02, pp.049. ⟨10.1007/JHEP02(2021)049⟩. ⟨hal-02410842⟩
    • Dietrich Averbeck, Claire Rodriguez-Lafrasse. Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts. Int.J.Mol.Sci., 2021, 22 (20), pp.11047. ⟨10.3390/ijms222011047⟩. ⟨hal-03450000⟩

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