Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    545 documents

    • Jayde Livingstone, Denis Dauvergne, A. Etxebeste, Mattia Fontana, Marie-Laure Gallin-Martel, et al.. Influence of sub-nanosecond time of flight resolution for online range verification in proton therapy using the line-cone reconstruction in Compton imaging. Physics in Medicine and Biology, 2021, 66, pp.125012. ⟨10.1088/1361-6560/ac03cb⟩. ⟨hal-03257804⟩
    • Franck Rabilloud, Janina Kopyra, Hassan Abdoul-Carime. Fragmentation of Nickel(II) and Cobalt(II) Bis(acetylacetonate) Complexes Induced by Slow (<10 eV) Electrons. Inorganic Chemistry, 2021, 60 (11), pp.8154-8163. ⟨10.1021/acs.inorgchem.1c00795⟩. ⟨hal-03281474⟩
    • H. Rabus, W.B. Li, C. Villagrasa, J. Schuemann, P.A. Hepperle, et al.. Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams. Physica Medica European Journal of Medical Physics, 2021, 84, pp.241-253. ⟨10.1016/j.ejmp.2021.03.005⟩. ⟨hal-03257934⟩
    • M.E. Alcover-Avila, A. Larouze, E. Hindlé, C. Champion, V. Levrague, et al.. Monte Carlo track structure simulations and the biophysical model NanOx in targeted radionuclide therapy. 1st International Workshop on Radiobiology of Molecular Radiotherapy, Mar 2021, Online, France. ⟨in2p3-04954666⟩
    • Floriane Poignant, Hela Charfi, Chen-Hui Chan, Elise Dumont, David Loffreda, et al.. Monte Carlo simulation of free radical production under keV photon irradiation of gold nanoparticle aqueous solution. Part II: Local primary chemical boost. Radiation Physics and Chemistry, 2021, 179, pp.109161. ⟨10.1016/j.radphyschem.2020.109161⟩. ⟨hal-03029595⟩
    • M.-L. Gallin-Martel, S. Curtoni, S. Marcatili, Latifa Abbassi, A. Bes, et al.. X-ray beam induced current analysis of CVD diamond detectors in the perspective of a beam tagging hodoscope development for hadrontherapy on-line monitoring. Diamond and Related Materials, 2021, 112, pp.108236. ⟨10.1016/j.diamond.2020.108236⟩. ⟨hal-03150914⟩
    • Hamid Ladjal, Michael Beuve, Philippe Giraud, Shariat Behzad. Towards Non-invasive Lung Tumor Tracking Based on Patient-Specific Model of Respiratory System. IEEE Transactions on Biomedical Engineering, 2021, 68 (9), pp.2730-2740. ⟨10.1109/TBME.2021.3053321⟩. ⟨hal-03113681⟩
    • Maxime Jacquet, Sara Marcatili, Marie-Laure Gallin-Martel, Jean-Luc Bouly, Yannick Boursier, et al.. A time-of-flight-based reconstruction for real-time prompt-gamma imaging in proton therapy. Physics in Medicine and Biology, 2021, 66 (13), pp.135003. ⟨10.1088/1361-6560/ac03ca⟩. ⟨hal-03319261⟩
    • Elise Rowinski, Nicolas Magne, Wafa Bouleftour, Pablo Moreno-Acosta, Christelle de La Fourchadiere, et al.. Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database. Cancer Genomics and Proteomics, 2021, 18 (4), pp.515-520. ⟨10.21873/cgp.20276⟩. ⟨hal-03323257⟩
    • Mamadou Soumboundou, Julien Dossou, Yossef Kalaga, Innocent Nkengurutse, Ibrahima Faye, et al.. Is Response to Genotoxic Stress Similar in Populations of African and European Ancestry? A Study of Dose-Response After in vitro Irradiation. Frontiers in Genetics, 2021, 12, pp.657999. ⟨10.3389/fgene.2021.657999⟩. ⟨hal-03472634⟩

    Powered by HAL logo