Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, N. Apadula, et al.. Nonperturbative transverse-momentum-dependent effects in dihadron and direct photon-hadron angular correlations in p+p collisions at \sqrt{s}=200 GeV. Physical Review D, 2018, 98 (7), pp.072004. ⟨10.1103/PhysRevD.98.072004⟩. ⟨hal-01802034⟩
    • S. Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Anisotropic flow in Xe-Xe collisions at \mathbf{\sqrt{s_{\rm{NN}}} = 5.44} TeV. Physics Letters B, 2018, 784, pp.82-95. ⟨10.1016/j.physletb.2018.06.059⟩. ⟨hal-01797143⟩
    • M.M. Vignetti, F. Calmon, P. Pittet, G. Pares, R. Cellier, et al.. 3D Silicon Coincidence Avalanche Detector (3D-SiCAD) for charged particle detection. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2018, 881, pp.53-59. ⟨10.1016/j.nima.2017.10.089⟩. ⟨hal-01703734⟩
    • Shreyasi Acharya, Jaroslav Adam, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. \pi ^{0} and \eta meson production in proton-proton collisions at \sqrt{s}=8 TeV. Eur.Phys.J.C, 2018, 78 (3), pp.263. ⟨10.1140/epjc/s10052-018-5612-8⟩. ⟨hal-01758328⟩
    • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. D-meson azimuthal anisotropy in midcentral Pb-Pb collisions at \mathbf{\sqrt{s_{\rm NN}}=5.02} TeV. Phys.Rev.Lett., 2018, 120 (10), pp.102301. ⟨10.1103/PhysRevLett.120.102301⟩. ⟨hal-01730085⟩
    • Dariia Ternova, Ali Ouadi, Valérie Mazan, Sylvia Georg, Maria Yu Boltoeva, et al.. New Ionic Liquid Based on the CMPO Pattern for the Sequential Extraction of U(VI), Am(III) and Eu(III). Journal of Solution Chemistry, 2018, 47 (8), pp.1309-1325. ⟨10.1007/s10953-018-0730-3⟩. ⟨hal-02271283⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of the Higgs boson decay to a pair of \tau leptons with the CMS detector. Phys.Lett.B, 2018, 779, pp.283-316. ⟨10.1016/j.physletb.2018.02.004⟩. ⟨hal-01725007⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the underlying event activity in inclusive Z boson production in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2018, 07, pp.032. ⟨10.1007/JHEP07(2018)032⟩. ⟨hal-01839680⟩
    • V. Andreev, A. Baghdasaryan, K. Begzsuren, A. Belousov, A. Bolz, et al.. Determination of electroweak parameters in polarised deep-inelastic scattering at HERA. European Physical Journal C: Particles and Fields, 2018, 78 (9), pp.777. ⟨10.1140/epjc/s10052-018-6236-8⟩. ⟨hal-01846597⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for top squarks decaying via four-body or chargino-mediated modes in single-lepton final states in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 09, pp.065. ⟨10.1007/JHEP09(2018)065⟩. ⟨hal-01801947⟩

    Powered by HAL logo