Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for single production of vector-like quarks decaying to a b quark and a Higgs boson. JHEP, 2018, 06, pp.031. ⟨10.1007/JHEP06(2018)031⟩. ⟨hal-01714127⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Electroweak production of two jets in association with a Z boson in proton–proton collisions at \sqrt{s}= 13 \,\text {TeV}. Eur.Phys.J.C, 2018, 78 (7), pp.589. ⟨10.1140/epjc/s10052-018-6049-9⟩. ⟨hal-01851321⟩
    • Benjamin P. Abbott, Rich Abbott, Thomas D. Abbott, Fausto Acernese, Kendall Ackley, et al.. Full Band All-sky Search for Periodic Gravitational Waves in the O1 LIGO Data. Physical Review D, 2018, 97 (10), pp.102003. ⟨10.1103/PhysRevD.97.102003⟩. ⟨hal-02999862⟩
    • Sacha Davidson, Yoshitaka Kuno, Albert Saporta. “Spin-dependent” {\mu \rightarrow e} conversion on light nuclei. European Physical Journal C: Particles and Fields, 2018, 78 (2), pp.109. ⟨10.1140/epjc/s10052-018-5584-8⟩. ⟨hal-01707635⟩
    • Daniel N. Blaschke, Francois Gieres, Stefan Hohenegger, Manfred Schweda, Michael Wohlgenannt. Field Theory with Coordinate Dependent Noncommutativity. SIGMA, 2018, 14, pp.133. ⟨10.3842/SIGMA.2018.133⟩. ⟨hal-01823208⟩
    • R. Maisonobe, J. Billard, M. de Jesus, A. Juillard, D. Misiak, et al.. Vibration decoupling system for massive bolometers in dry cryostats. Journal of Instrumentation, 2018, 13 (08), pp.T08009. ⟨10.1088/1748-0221/13/08/T08009⟩. ⟨hal-01758057⟩
    • M.M. Vignetti, F. Calmon, P. Pittet, G. Pares, R. Cellier, et al.. 3D Silicon Coincidence Avalanche Detector (3D-SiCAD) for charged particle detection. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2018, 881, pp.53-59. ⟨10.1016/j.nima.2017.10.089⟩. ⟨hal-01703734⟩
    • Dariia Ternova, Ali Ouadi, ValĂ©rie Mazan, Sylvia Georg, Maria Yu Boltoeva, et al.. New Ionic Liquid Based on the CMPO Pattern for the Sequential Extraction of U(VI), Am(III) and Eu(III). Journal of Solution Chemistry, 2018, 47 (8), pp.1309-1325. ⟨10.1007/s10953-018-0730-3⟩. ⟨hal-02271283⟩
    • David Andriot, Dimitrios Tsimpis. Laplacian spectrum on a nilmanifold, truncations and effective theories. Journal of High Energy Physics, 2018, 09, pp.096. ⟨10.1007/JHEP09(2018)096⟩. ⟨hal-01827995⟩
    • Victor Mukhamedovich Abazov, Braden Keim Abbott, Bannanje Sripath Acharya, Mark Raymond Adams, Todd Adams, et al.. Measurement of the Effective Weak Mixing Angle in p\bar{p}\rightarrow Z/\gamma^* \rightarrow \ell^+\ell^- Events. Phys.Rev.Lett., 2018, 120 (24), pp.241802. ⟨10.1103/PhysRevLett.120.241802⟩. ⟨hal-01823317⟩

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