Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

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- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Search for supersymmetry with Higgs boson to diphoton decays using the razor variables at \sqrt{s} = 13 TeV. Phys.Lett.B, 2018, 779, pp.166-190. ⟨10.1016/j.physletb.2017.12.069⟩. ⟨hal-01714695⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Bose-Einstein correlations in pp, p\mathrm{Pb}, and PbPb collisions at \sqrt{{s}_{NN}}=0.9-7 TeV. Physical Review C, 2018, 97 (6), pp.064912. ⟨10.1103/PhysRevC.97.064912⟩. ⟨hal-01818307⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Evidence for the associated production of a single top quark and a photon in proton-proton collisions at \sqrt{s}= 13 TeV. Physical Review Letters, 2018, 121 (22), pp.221802. ⟨10.1103/PhysRevLett.121.221802⟩. ⟨hal-01861868⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for single production of vector-like quarks decaying to a b quark and a Higgs boson. JHEP, 2018, 06, pp.031. ⟨10.1007/JHEP06(2018)031⟩. ⟨hal-01714127⟩
  • Shreyasi Acharya, Jaroslav Adam, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Constraining the magnitude of the Chiral Magnetic Effect with Event Shape Engineering in Pb-Pb collisions at \sqrt{s_\mathrm{NN}} = 2.76 TeV. Physics Letters B, 2018, 777, pp.151-162. ⟨10.1016/j.physletb.2017.12.021⟩. ⟨hal-01703736⟩
  • H. Abramowicz, I. Abt, L. Adamczyk, M. Adamus, R. Aggarwal, et al.. Combination and QCD analysis of charm and beauty production cross-section measurements in deep inelastic ep scattering at HERA. Eur.Phys.J.C, 2018, 78 (6), pp.473. ⟨10.1140/epjc/s10052-018-5848-3⟩. ⟨hal-01797099⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a heavy resonance decaying into a Z boson and a vector boson in the \nu \overline{\nu}\mathrm{q}\overline{\mathrm{q}} final state. JHEP, 2018, 07, pp.075. ⟨10.1007/JHEP07(2018)075⟩. ⟨hal-01758715⟩
  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for resonant pair production of Higgs bosons decaying to bottom quark-antiquark pairs in proton-proton collisions at 13 TeV. JHEP, 2018, 08, pp.152. ⟨10.1007/JHEP08(2018)152⟩. ⟨hal-01833687⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for ZZ resonances in the 2\ell2\nu final state in proton-proton collisions at 13 TeV. JHEP, 2018, 03, pp.003. ⟨10.1007/JHEP03(2018)003⟩. ⟨hal-01730118⟩
  • Abdulhamid Chaikh, Jarkko Ojala, Catherine Khamphan, Robin Garcia, Jean Yves Giraud, et al.. Dosimetrical and radiobiological approach to manage the dosimetric shift in the transition of dose calculation algorithm in radiation oncology: how to improve high quality treatment and avoid unexpected outcomes?. Radiat.Oncol., 2018, 13 (1), pp.60. ⟨10.1186/s13014-018-1005-2⟩. ⟨hal-02065773⟩

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