Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Bose-Einstein correlations in pp, p\mathrm{Pb}, and PbPb collisions at \sqrt{{s}_{NN}}=0.9-7 TeV. Physical Review C, 2018, 97 (6), pp.064912. ⟨10.1103/PhysRevC.97.064912⟩. ⟨hal-01818307⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for single production of vector-like quarks decaying to a b quark and a Higgs boson. JHEP, 2018, 06, pp.031. ⟨10.1007/JHEP06(2018)031⟩. ⟨hal-01714127⟩
  • Julien Billard, Joseph Johnston, Bradley J. Kavanagh. Prospects for exploring New Physics in Coherent Elastic Neutrino-Nucleus Scattering. Journal of Cosmology and Astroparticle Physics, 2018, 11, pp.016. ⟨10.1088/1475-7516/2018/11/016⟩. ⟨hal-01797124⟩
  • Zhiheng Wang, Qiang Zhao, Haozhao Liang, Wen Hui Long. Quantitative analysis of tensor effects in the relativistic Hartree-Fock theory. Phys.Rev.C, 2018, 98 (3), pp.034313. ⟨10.1103/PhysRevC.98.034313⟩. ⟨hal-01846804⟩
  • S. Aghion, C. Amsler, M. Antonello, A. Belov, G. Bonomi, et al.. Antiproton tagging and vertex fitting in a Timepix3 detector. Journal of Instrumentation, 2018, 13 (06), pp.P06004. ⟨10.1088/1748-0221/13/06/P06004⟩. ⟨hal-01833684⟩
  • S. Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. \phi meson production at forward rapidity in Pb-Pb collisions at \sqrt{s_\mathrm{NN}}=2.76 TeV. European Physical Journal C: Particles and Fields, 2018, 78 (7), pp.559. ⟨10.1140/epjc/s10052-018-6034-3⟩. ⟨hal-01796887⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new physics in events with two soft oppositely charged leptons and missing transverse momentum in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Lett.B, 2018, 782, pp.440-467. ⟨10.1016/j.physletb.2018.05.062⟩. ⟨hal-01891038⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for an exotic decay of the Higgs boson to a pair of light pseudoscalars in the final state of two muons and two \tau leptons in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2018, 11, pp.018. ⟨10.1007/JHEP11(2018)018⟩. ⟨hal-01801910⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the flavor-changing neutral current interactions of the top quark and the Higgs boson which decays into a pair of b quarks at \sqrt{s}= 13 TeV. JHEP, 2018, 06, pp.102. ⟨10.1007/JHEP06(2018)102⟩. ⟨hal-01833764⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new phenomena in final states with two opposite-charge, same-flavor leptons, jets, and missing transverse momentum in pp collisions at \sqrt{s}=13 TeV. JHEP, 2018, 03, pp.076. ⟨10.1007/s13130-018-7845-2⟩. ⟨hal-01758769⟩

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