Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • H.J. Li, J. Ljungvall, C. Michelagnoli, E. ClĂ©ment, J. Dudouet, et al.. Experimental determination of reference pulses for highly segmented HPGe detectors and application to Pulse Shape Analysis used in \gamma -ray tracking arrays. The European physical journal. A, Hadrons and Nuclei, 2018, 54 (11), pp.198. ⟨10.1140/epja/i2018-12636-9⟩. ⟨hal-01952713⟩
    • R. Bougault, E. Bonnet, B. Borderie, A. Chbihi, D. Dell'Aquila, et al.. Light charged clusters emitted in 32 MeV/nucleon ^{136,124}Xe+^{124,112}Sn reactions: Chemical equilibrium and production of ^{3}He and ^{6}He. Physical Review C, 2018, 97 (2), pp.024612. ⟨10.1103/PhysRevC.97.024612⟩. ⟨hal-01719992⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a massive resonance decaying to a pair of Higgs bosons in the four b quark final state in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Lett.B, 2018, 781, pp.244-269. ⟨10.1016/j.physletb.2018.03.084⟩. ⟨hal-01768077⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new physics in events with a leptonically decaying Z boson and a large transverse momentum imbalance in proton–proton collisions at \sqrt{s} = 13 \,\text {TeV}. Eur.Phys.J.C, 2018, 78 (4), pp.291. ⟨10.1140/epjc/s10052-018-5740-1⟩. ⟨hal-01768075⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the Splitting Function in pp and Pb-Pb Collisions at \sqrt{s_{_{\mathrm{NN}}}} = 5.02 TeV. Phys.Rev.Lett., 2018, 120 (14), pp.142302. ⟨10.1103/PhysRevLett.120.142302⟩. ⟨hal-01764019⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for vector-like T and B quark pairs in final states with leptons at \sqrt{s} = 13 TeV. JHEP, 2018, 08, pp.177. ⟨10.1007/JHEP08(2018)177⟩. ⟨hal-01801904⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Pseudorapidity distributions of charged hadrons in proton-lead collisions at \sqrt{s_{_\mathrm{NN}}} = 5.02 and 8.16 TeV. JHEP, 2018, 01, pp.045. ⟨10.1007/JHEP01(2018)045⟩. ⟨hal-01703784⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Performance of the CMS muon detector and muon reconstruction with proton-proton collisions at \sqrt{s}= 13 TeV. JINST, 2018, 13 (06), pp.P06015. ⟨10.1088/1748-0221/13/06/P06015⟩. ⟨hal-01782018⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for disappearing tracks as a signature of new long-lived particles in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 08, pp.016. ⟨10.1007/JHEP08(2018)016⟩. ⟨hal-01782017⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of differential cross sections for Z boson production in association with jets in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2018, 78 (11), pp.965. ⟨10.1140/epjc/s10052-018-6373-0⟩. ⟨hal-01782015⟩

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