Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a singly produced third-generation scalar leptoquark decaying to a \tau lepton and a bottom quark in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 07, pp.115. ⟨10.1007/JHEP07(2018)115⟩. ⟨hal-01833688⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV. JINST, 2018, 13 (05), pp.P05011. ⟨10.1088/1748-0221/13/05/P05011⟩. ⟨hal-01797401⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Combined search for electroweak production of charginos and neutralinos in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 03, pp.160. ⟨10.1007/JHEP03(2018)160⟩. ⟨hal-01703674⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for dark matter in events with energetic, hadronically decaying top quarks and missing transverse momentum at \sqrt{s}=13 TeV. JHEP, 2018, 06, pp.027. ⟨10.1007/JHEP06(2018)027⟩. ⟨hal-01703561⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the \Lambda_b polarization and angular parameters in \Lambda_b\to J/\psi\, \Lambda decays from pp collisions at \sqrt{s}= 7 and 8 TeV. Phys.Rev.D, 2018, 97 (7), pp.072010. ⟨10.1103/PhysRevD.97.072010⟩. ⟨hal-01724870⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Azimuthal correlations for inclusive 2-jet, 3-jet, and 4-jet events in pp collisions at \sqrt{s}= 13 TeV. Eur.Phys.J.C, 2018, 78 (7), pp.566. ⟨10.1140/epjc/s10052-018-6033-4⟩. ⟨hal-01839648⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Measurements of t\bar{t} cross sections in association with b jets and inclusive jets and their ratio using dilepton final states in pp collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2018, 776, pp.355-378. ⟨10.1016/j.physletb.2017.11.043⟩. ⟨hal-01669734⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of Higgs boson properties in the diphoton decay channel in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 11, pp.185. ⟨10.1007/JHEP11(2018)185⟩. ⟨hal-01774093⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for beyond the standard model Higgs bosons decaying into a \mathrm{b\overline{b}} pair in pp collisions at \sqrt{s} = 13 TeV. JHEP, 2018, 08, pp.113. ⟨10.1007/JHEP08(2018)113⟩. ⟨hal-01815216⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Constraints on models of scalar and vector leptoquarks decaying to a quark and a neutrino at \sqrt{s}= 13 TeV. Phys.Rev.D, 2018, 98 (3), pp.032005. ⟨10.1103/PhysRevD.98.032005⟩. ⟨hal-01815202⟩

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