Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • A. M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new physics in final states with an energetic jet or a hadronically decaying W or Z boson and transverse momentum imbalance at \sqrt{s}=13\text{ }\text{ }\mathrm{TeV}. Phys.Rev.D, 2018, 97 (9), pp.092005. ⟨10.1103/PhysRevD.97.092005⟩. ⟨hal-01801989⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new long-lived particles at \sqrt{s} = 13 TeV. Phys.Lett.B, 2018, 780, pp.432-454. ⟨10.1016/j.physletb.2018.03.019⟩. ⟨hal-01797856⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for high-mass resonances in dilepton final states in proton-proton collisions at \sqrt{s}= 13 TeV. JHEP, 2018, 06, pp.120. ⟨10.1007/JHEP06(2018)120⟩. ⟨hal-01758150⟩
  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for pair-produced resonances each decaying into at least four quarks in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Rev.Lett., 2018, 121 (14), pp.141802. ⟨10.1103/PhysRevLett.121.141802⟩. ⟨hal-01817967⟩
  • Victor Mukhamedovich Abazov, Braden Keim Abbott, Bannanje Sripath Acharya, Mark Raymond Adams, Todd Adams, et al.. Study of the {X^\pm(5568)} state with semileptonic decays of the {B_s^0} meson. Phys.Rev.D, 2018, 97 (9), pp.092004. ⟨10.1103/PhysRevD.97.092004⟩. ⟨hal-01802064⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for \mathrm{t}\overline{\mathrm{t}}H production in the all-jet final state in proton-proton collisions at \sqrt{s}= 13 TeV. JHEP, 2018, 06, pp.101. ⟨10.1007/JHEP06(2018)101⟩. ⟨hal-01763485⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for pair production of excited top quarks in the lepton + jets final state. Phys.Lett.B, 2018, 778, pp.349-370. ⟨10.1016/j.physletb.2018.01.049⟩. ⟨hal-01704846⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Inclusive J/\psi production at forward and backward rapidity in p-Pb collisions at \sqrt{s_{\rm NN}} = 8.16 TeV. Journal of High Energy Physics, 2018, 07, pp.160. ⟨10.1007/JHEP07(2018)160⟩. ⟨hal-01801876⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of differential cross sections of top quark pair production as a function of kinematic event variables in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2018, 06, pp.002. ⟨10.1007/JHEP06(2018)002⟩. ⟨hal-01758717⟩
  • S. Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Azimuthally-differential pion femtoscopy relative to the third harmonic event plane in Pb-Pb collisions at \mathbf{\sqrt{\textit{s}_{_{\rm NN}}}} = 2.76 TeV. Physics Letters B, 2018, 785, pp.320-331. ⟨10.1016/j.physletb.2018.06.042⟩. ⟨hal-01768140⟩

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