Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for resonant and nonresonant Higgs boson pair production in the \mathrm{b}\overline{\mathrm{b}}\mathit{\ell \nu \ell \nu } final state in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2018, 01, pp.054. ⟨10.1007/JHEP01(2018)054⟩. ⟨hal-01704891⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Study of dijet events with a large rapidity gap between the two leading jets in pp collisions at \sqrt {s} = 7 TeV. Eur.Phys.J.C, 2018, 78 (3), pp.242. ⟨10.1140/epjc/s10052-018-5691-6⟩. ⟨hal-01758283⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for long-lived particles with displaced vertices in multijet events in proton-proton collisions at \sqrt{s}=13 TeV. Phys.Rev.D, 2018, 98 (9), pp.092011. ⟨10.1103/PhysRevD.98.092011⟩. ⟨hal-01861877⟩
    • A. Adare, S. Afanasiev, C. Aidala, N.N. Ajitanand, Y. Akiba, et al.. Low-momentum direct photon measurement in Cu+Cu collisions at \sqrt{s_{_{NN}}}=200 GeV. Physical Review C, 2018, 98 (5), pp.054902. ⟨10.1103/PhysRevC.98.054902⟩. ⟨hal-01801850⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Nuclear modification factor of D^0 mesons in PbPb collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Phys.Lett.B, 2018, 782, pp.474-496. ⟨10.1016/j.physletb.2018.05.074⟩. ⟨hal-01815262⟩
    • A. Helmi, F. van Leeuwen, P. J. Mc Millan, D. Massari, T. Antoja, et al.. VizieR Online Data Catalog: Gaia DR2 sources in GC and dSph (Gaia Collaboration+, 2018). 2018, ⟨10.26093/cds/vizier.36160012⟩. ⟨hal-01867447⟩
    • Jérôme Margueron, Rudiney Hoffmann Casali, Francesca Gulminelli. Equation of state for dense nucleonic matter from metamodeling. II. Predictions for neutron star properties. Physical Review C, 2018, 97 (2), pp.025806. ⟨10.1103/PhysRevC.97.025806⟩. ⟨hal-01725001⟩
    • D. Adamová, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, Michelangelo Agnello, Neelima Agrawal, et al.. J/\psi production as a function of charged-particle pseudorapidity density in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Phys.Lett.B, 2018, 776, pp.91-104. ⟨10.1016/j.physletb.2017.11.008⟩. ⟨hal-01669479⟩
    • S. Acharya, Jaroslav Adam, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Longitudinal asymmetry and its effect on pseudorapidity distributions in Pb-Pb collisions at \sqrt{s_{NN}} = 2.76 TeV. Phys.Lett.B, 2018, 781, pp.20-32. ⟨10.1016/j.physletb.2018.03.051⟩. ⟨hal-01768021⟩
    • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. Production of ^{4}He and ^{4}\overline{\textrm{He}} in Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}} = 2.76 TeV at the LHC. Nucl.Phys.A, 2018, 971, pp.1-20. ⟨10.1016/j.nuclphysa.2017.12.004⟩. ⟨hal-01704400⟩

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