Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for heavy resonances decaying into a vector boson and a Higgs boson in final states with charged leptons, neutrinos and b quarks at \sqrt{s}=13 TeV. JHEP, 2018, 11, pp.172. ⟨10.1007/JHEP11(2018)172⟩. ⟨hal-01846640⟩
  • K. Abe, J. Amey, C. Andreopoulos, M. Antonova, S. Aoki, et al.. Measurement of the single \pi^0 production rate in neutral current neutrino interactions on water. Physical Review D, 2018, 97 (3), pp.032002. ⟨10.1103/PhysRevD.97.032002⟩. ⟨hal-01703794⟩
  • L. Feketeová, A. Pelc, A. Ribar, S.E. Huber, S. Denifl. Dissociation of methyl formate (HCOOCH_3) molecules upon low-energy electron attachment. Astronomy & Astrophysics - A&A, 2018, 617, pp.A102. ⟨10.1051/0004-6361/201732293⟩. ⟨hal-01983007⟩
  • Jusuf M. Khreis, Sukanya Pandeti, Linda Feketeová, Stephan Denifl. High-energy collision-induced dissociation of radiosensitizer anions: Nimorazole and metronidazole. Int.J.Mass Spectrometry, 2018, 431, pp.1-7. ⟨10.1016/j.ijms.2018.05.015⟩. ⟨hal-01959778⟩
  • Giacomo Cacciapaglia, Gabriele Ferretti, Thomas Flacke, Hugo Serodio. Revealing timid pseudo-scalars with taus at the LHC. European Physical Journal C: Particles and Fields, 2018, 78 (9), pp.724. ⟨10.1140/epjc/s10052-018-6183-4⟩. ⟨hal-01876839⟩
  • C. Aidala, N.N. Ajitanand, Y. Akiba, R. Akimoto, J. Alexander, et al.. Production of \pi^0 and \eta mesons in Cu+Au collisions at \sqrt{s_{_{NN}}}=200 GeV. Physical Review C, 2018, 98 (5), pp.054903. ⟨10.1103/PhysRevC.98.054903⟩. ⟨hal-01801887⟩
  • A. Adare, C. Aidala, N.N. Ajitanand, Y. Akiba, R. Akimoto, et al.. Cross section and longitudinal single-spin asymmetry A_L for forward W^{\pm}\rightarrow\mu^{\pm}\nu production in polarized p+p collisions at \sqrt{s}=510 GeV. Physical Review D, 2018, 98 (3), pp.032007. ⟨10.1103/PhysRevD.98.032007⟩. ⟨hal-01781922⟩
  • Mohammed Daoud, Maurice Robert Kibler. Generalized Weyl-Heisenberg algebra, qudit systems and entanglement measure of symmetric states via spin coherent states. Entropy, 2018, 20 (4), pp.292. ⟨10.3390/e20040292⟩. ⟨in2p3-01767266⟩
  • Janina Kopyra, Franck Rabilloud, Hassan Abdoul-Carime. Interaction of gas phase copper(II) acetylacetonate with slow electrons. Physical Chemistry Chemical Physics, 2018, 20 (11), pp.7746-7753. ⟨10.1039/C7CP08149A⟩. ⟨hal-01867280⟩
  • N. Galy, N. Toulhoat, N. Moncoffre, Y. Pipon, N. Bererd, et al.. Ion irradiation used as surrogate of neutron irradiation in graphite: Consequences on ^{14}C and ^{36}Cl behavior and structural evolution. Journal of Nuclear Materials, 2018, 502, pp.20-29. ⟨10.1016/j.jnucmat.2018.01.058⟩. ⟨hal-01867282⟩

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