Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • M. Fontana, D. Dauvergne, R. Della Negra, J.M. Létang, F. Mounier, et al.. Large surface gamma cameras for medical imaging: characterization of the bismuth germanate blocks. Journal of Instrumentation, 2018, 13, pp.P08018. ⟨10.1088/1748-0221/13/08/P08018⟩. ⟨hal-01871818⟩
    • L. Gallego Manzano, J.M. Abaline, S. Acounis, N. Beaupère, J.L. Beney, et al.. XEMIS2: A liquid xenon detector for small animal medical imaging. Nucl.Instrum.Meth.A, 2018, 912, pp.329-332. ⟨10.1016/j.nima.2017.12.022⟩. ⟨hal-02317373⟩
    • Mohammed Daoud, Maurice Robert Kibler. Generalized Weyl-Heisenberg algebra, qudit systems and entanglement measure of symmetric states via spin coherent states. Entropy, 2018, 20 (4), pp.292. ⟨10.3390/e20040292⟩. ⟨in2p3-01767266⟩
    • Giacomo Cacciapaglia, Gabriele Ferretti, Thomas Flacke, Hugo Serodio. Revealing timid pseudo-scalars with taus at the LHC. European Physical Journal C: Particles and Fields, 2018, 78 (9), pp.724. ⟨10.1140/epjc/s10052-018-6183-4⟩. ⟨hal-01876839⟩
    • Shreyasi Acharya, Jaroslav Adam, Dagmar Adamova, Clemens Adler, Jonatan Adolfsson, et al.. The ALICE Transition Radiation Detector: construction, operation, and performance. Nucl.Instrum.Meth.A, 2018, 881, pp.88-127. ⟨10.1016/j.nima.2017.09.028⟩. ⟨hal-02485101⟩
    • S. Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Azimuthally-differential pion femtoscopy relative to the third harmonic event plane in Pb-Pb collisions at \mathbf{\sqrt{\textit{s}_{_{\rm NN}}}} = 2.76 TeV. Physics Letters B, 2018, 785, pp.320-331. ⟨10.1016/j.physletb.2018.06.042⟩. ⟨hal-01768140⟩
    • S. Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Anisotropic flow of identified particles in Pb-Pb collisions at {\sqrt{s}}_{\mathrm{NN}}=5.02 TeV. Journal of High Energy Physics, 2018, 09, pp.006. ⟨10.1007/JHEP09(2018)006⟩. ⟨hal-01801884⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Inclusive J/\psi production at forward and backward rapidity in p-Pb collisions at \sqrt{s_{\rm NN}} = 8.16 TeV. Journal of High Energy Physics, 2018, 07, pp.160. ⟨10.1007/JHEP07(2018)160⟩. ⟨hal-01801876⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Measurements of low-p_{T} electrons from semileptonic heavy-flavour hadron decays at mid-rapidity in pp and Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}}=2.76 TeV. Journal of High Energy Physics, 2018, 10, pp.061. ⟨10.1007/JHEP10(2018)061⟩. ⟨hal-01801878⟩
    • Janina Kopyra, Franck Rabilloud, Hassan Abdoul-Carime. Interaction of gas phase copper(II) acetylacetonate with slow electrons. Phys.Chem.Chem.Phys., 2018, 20 (11), pp.7746-7753. ⟨10.1039/c7cp08149a⟩. ⟨hal-01867280⟩

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