Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Q. Arnaud, E. Armengaud, C. Augier, A. Benoît, L. Bergé, et al.. Optimizing EDELWEISS detectors for low-mass WIMP searches. Physical Review D, 2018, 97 (2), pp.022003. ⟨10.1103/PhysRevD.97.022003⟩. ⟨hal-01703622⟩
    • Giacomo Cacciapaglia, Aldo Deandrea, Naveen Gaur, Daisuke Harada, Yasuhiro Okada, et al.. The LHC potential of Vector-like quark doublets. Journal of High Energy Physics, 2018, 11, pp.055. ⟨10.1007/JHEP11(2018)055⟩. ⟨hal-01817904⟩
    • A. Belyaev, G. Cacciapaglia, Igor P. Ivanov, F. Rojas, M. Thomas. Anatomy of the Inert Two Higgs Doublet Model in the light of the LHC and non-LHC Dark Matter Searches. Physical Review D, 2018, 97, pp.035011. ⟨10.1103/PhysRevD.97.035011⟩. ⟨in2p3-01437094⟩
    • Alessandro Roggero, Jérôme Margueron, Luke F. Roberts, Sanjay Reddy. Nuclear pasta in hot dense matter and its implications for neutrino scattering. Physical Review C, 2018, 97 (4), pp.045804. ⟨10.1103/PhysRevC.97.045804⟩. ⟨hal-01774617⟩
    • Benoîte Mery, Sophie Espenel, Jean-Baptiste Guy, Chloé Rancoule, Alexis Vallard, et al.. Biological aspects of chondrosarcoma: Leaps and hurdles. Crit.Rev.Oncol.Hematol., 2018, 126, pp.32-36. ⟨10.1016/j.critrevonc.2018.03.009⟩. ⟨hal-01867855⟩
    • K. Hadyńska-Klȩk, P.J. Napiorkowski, M. Zielińska, J. Srebrny, A. Maj, et al.. Quadrupole collectivity in ^{42}\mathrm{Ca} from low-energy Coulomb excitation with AGATA. Physical Review C, 2018, 97 (2), pp.024326. ⟨10.1103/PhysRevC.97.024326⟩. ⟨hal-01730128⟩
    • S. Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. First measurement of \Xi_{\rm c}^0 production in pp collisions at \mathbf{\sqrt{s}} = 7 TeV. Phys.Lett.B, 2018, 781, pp.8-19. ⟨10.1016/j.physletb.2018.03.061⟩. ⟨hal-01768086⟩
    • A. Adare, C. Aidala, N.N. Ajitanand, Y. Akiba, M. Alfred, et al.. Pseudorapidity Dependence of Particle Production and Elliptic Flow in Asymmetric Nuclear Collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at \sqrt{s_{_{NN}}}=200 GeV. Physical Review Letters, 2018, 121 (22), pp.222301. ⟨10.1103/PhysRevLett.121.222301⟩. ⟨hal-01861975⟩
    • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, N. Apadula, et al.. Single-spin asymmetry of J/\psi production in p+p, p+Al, and p+Au collisions with transversely polarized proton beams at \sqrt{s_{_{NN}}}=200 GeV. Physical Review D, 2018, 98 (1), pp.012006. ⟨10.1103/PhysRevD.98.012006⟩. ⟨hal-01802030⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Medium modification of the shape of small-radius jets in central Pb-Pb collisions at \sqrt{s_{\mathrm {NN}}} = 2.76\,\rm{TeV}. Journal of High Energy Physics, 2018, 10, pp.139. ⟨10.1007/JHEP10(2018)139⟩. ⟨hal-01861922⟩

    Powered by HAL logo