Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • S. Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Transverse momentum spectra and nuclear modification factors of charged particles in pp, p-Pb and Pb-Pb collisions at the LHC. Journal of High Energy Physics, 2018, 11, pp.013. ⟨10.1007/JHEP11(2018)013⟩. ⟨hal-01729959⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Pseudorapidity and transverse momentum dependence of flow harmonics in pPb and PbPb collisions. Physical Review C, 2018, 98 (4), pp.044902. ⟨10.1103/PhysRevC.98.044902⟩. ⟨hal-01891657⟩
  • K. Hadyńska-Klȩk, P.J. Napiorkowski, M. Zielińska, J. Srebrny, A. Maj, et al.. Quadrupole collectivity in ^{42}\mathrm{Ca} from low-energy Coulomb excitation with AGATA. Physical Review C, 2018, 97 (2), pp.024326. ⟨10.1103/PhysRevC.97.024326⟩. ⟨hal-01730128⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Constraints on the chiral magnetic effect using charge-dependent azimuthal correlations in p\mathrm{Pb} and PbPb collisions at the CERN Large Hadron Collider. Physical Review C, 2018, 97 (4), pp.044912. ⟨10.1103/PhysRevC.97.044912⟩. ⟨hal-01782023⟩
  • A. M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of Higgs boson decay to bottom quarks. Phys.Rev.Lett., 2018, 121 (12), pp.121801. ⟨10.1103/PhysRevLett.121.121801⟩. ⟨hal-01871805⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for third-generation scalar leptoquarks decaying to a top quark and a \tau lepton at \sqrt{s}= 13 TeV. Eur.Phys.J.C, 2018, 78, pp.707. ⟨10.1140/epjc/s10052-018-6143-z⟩. ⟨hal-01758566⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for pair-produced resonances decaying to quark pairs in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Rev.D, 2018, 98 (11), pp.112014. ⟨10.1103/PhysRevD.98.112014⟩. ⟨hal-01861880⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for top squarks and dark matter particles in opposite-charge dilepton final states at \sqrt{s}= 13 TeV. Phys.Rev.D, 2018, 97 (3), pp.032009. ⟨10.1103/PhysRevD.97.032009⟩. ⟨hal-01714245⟩
  • A. M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the X(5568) state decaying into \mathrm{B}^{0}_{\mathrm{s}}\pi^{\pm} in proton-proton collisions at \sqrt{s} = 8 TeV. Phys.Rev.Lett., 2018, 120 (20), pp.202005. ⟨10.1103/PhysRevLett.120.202005⟩. ⟨hal-01802092⟩
  • A. M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of the \chi_\mathrm{b1}(3P) and \chi_\mathrm{b2}(3P) and measurement of their masses. Phys.Rev.Lett., 2018, 121, pp.092002. ⟨10.1103/PhysRevLett.121.092002⟩. ⟨hal-01815242⟩

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