Health (PRISME)

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  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    545 documents

    • Marie-ThĂ©rèse Aloy, Jacqueline Sidi Boumedine, Agathe Deville, David Kryza, Arnaud Gauthier, et al.. Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma. International Journal of Nanomedicine, 2022, Volume 17, pp.6655-6673. ⟨10.2147/IJN.S390056⟩. ⟨hal-04112046⟩
    • Magdalena Garbacz, Jan Gajewski, Marco Durante, Kamil Kisielewicz, Nils Krah, et al.. Quantification of biological range uncertainties in patients treated at the Krakow proton therapy centre. RADIATION ONCOLOGY, 2022, 17 (1), pp.50. ⟨10.1186/s13014-022-02022-5⟩. ⟨hal-03615439⟩
    • Yasmine Ali. Biological dose estimation in hadrontherapy using the GATE Monte Carlo simulation platform. Physics [physics]. UniversitĂ© de Lyon, 2021. English. ⟨NNT : 2021LYSE1329⟩. ⟨tel-03783569⟩
    • Elodie A Courtois, Wafa Bouleftour, Jean-Baptiste Guy, Safa Louati, RenĂ©-Jean Bensadoun, et al.. Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review. BMC Oral Health, 2021, 21 (1), ⟨10.1186/s12903-021-01574-4⟩. ⟨hal-03326520⟩
    • C. Rodriguez-Lafrasse. Cellular and Molecular Radiobiology Lab ( LRCM) activities. CNAO-IN2P3 collaboration meeting, Nov 2021, Pavia, Italy. ⟨in2p3-04955963⟩
    • E. Testa. Planning Innovative Cancer Therapies Using RadioElements: the PICTURE project. CNAO-IN2P3 collaboration meeting, Nov 2021, Pavia, Italy. ⟨in2p3-04955959⟩
    • A.-S. Wozny, G. Alphonse, A. Gauthier, C. Malesys, V. Varoclier, et al.. Role of HIF-1 \alpha in the detection signaling and repair of DNA double-strand breaks after photon and carbon-ion exposure. 46th Annual Meeting of the European Radiation Research Society (ERRS 2021), Nov 2021, Caen, France. ⟨in2p3-04956644⟩
    • Michael Eliezer, Guillaume Poillon, Julien Horion, Phillipe Lelion, Emmanuel Gerardin, et al.. MRI diagnosis of saccular hydrops: Comparison of heavily-T2 FIESTA-C and 3D-FLAIR sequences with delayed acquisition. Journal de Neuroradiologie / Journal of Neuroradiology, 2021, 48 (6), pp.446-452. ⟨10.1016/j.neurad.2019.04.005⟩. ⟨hal-04841547⟩
    • David Sarrut, Ane Etxebeste, Enrique Muñoz, Nils Krah, J.-M. Letang. Artificial Intelligence for Monte Carlo Simulation in Medical Physics. Frontiers in Physics, 2021, 9, ⟨10.3389/fphy.2021.738112⟩. ⟨hal-03409138⟩
    • R. Delorme, M.P. Rivera, M.A. Avila, V. Levrague, C. Alphone, et al.. The PICTURE project:toward biological dose prediction of tardeted radiotherapies emitting short-range ions. 9th International Conference on Computer Science and Network Technology (ICCSNT 2021), Oct 2021, Dailan, China. ⟨in2p3-04937361⟩

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