Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • David Sarrut, A. Etxebeste, Nils Krah, Jean Michel Létang. Modeling complex particles phase space with GAN for Monte Carlo SPECT simulations: a proof of concept. Physics in Medicine and Biology, 2021, 66 (5), pp.055014. ⟨10.1088/1361-6560/abde9a⟩. ⟨hal-03150535⟩
  • David Sarrut, Mateusz Bała, Manuel Bardiès, Julien Bert, Maxime Chauvin, et al.. Advanced Monte Carlo simulations of emission tomography imaging systems with GATE. Physics in Medicine and Biology, 2021, 66 (10), pp.10TR03. ⟨10.1088/1361-6560/abf276⟩. ⟨hal-03229364⟩
  • Sébastien Curtoni, Marie-Laure Gallin-Martel, Latifa Abbassi, Alexandre Bes, Germain Bosson, et al.. Performance of CVD diamond detectors for single ion beam-tagging applications in hadrontherapy monitoring. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2021, 1015, pp.165757. ⟨10.1016/j.nima.2021.165757⟩. ⟨hal-03227464⟩
  • Janina Kopyra, Franck Rabilloud, Paulina Wierzbicka, Hassan Abdoul-Carime. Energy-Selective Decomposition of Organometallic Compounds by Slow Electrons: The Case of Chloro(dimethyl sulfide)gold(I). Journal of Physical Chemistry A, 2021, 125 (4), pp.966-972. ⟨10.1021/acs.jpca.0c09988⟩. ⟨hal-03148189⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Measurement of differential cross sections for Z bosons produced in association with charm jets in pp collisions at \sqrt{s} = 13 TeV. Journal of High Energy Physics, 2021, 04, pp.109. ⟨10.1007/JHEP04(2021)109⟩. ⟨hal-03098853⟩
  • X. Liu, B. Cederwall, C. Qi, R.A. Wyss, Ö. Aktas, et al.. Evidence for enhanced neutron-proton correlations from the level structure of the N=Z+1 nucleus _{43}^{87}\mathrm{Tc}_{44}. Physical Review C, 2021, 104 (2), pp.L021302. ⟨10.1103/PhysRevC.104.L021302⟩. ⟨hal-03335724⟩
  • Elise Rowinski, Nicolas Magné, Jérôme Fayette, Elisabeth Daguenet, Séverine Racadot, et al.. Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub‐analysis of the ProfiLER protocol. Head & Neck, 2021, 43 (12), pp.3899-3910. ⟨10.1002/hed.26891⟩. ⟨hal-03461669⟩
  • Dany Davesne, Alessandro Pastore, Jesus Navarro. Linear response theory with finite-range interactions. Progress in Particle and Nuclear Physics, 2021, 120, pp.103870. ⟨10.1016/j.ppnp.2021.103870⟩. ⟨hal-03047570⟩
  • J. Dobaczewski, P. Bączyk, P. Becker, M. Bender, K. Bennaceur, et al.. Solution of universal nonrelativistic nuclear DFT equations in the Cartesian deformed harmonic-oscillator basis. (IX) HFODD (v3.06h): a new version of the program. J.Phys.G, 2021, 48 (10), pp.102001. ⟨10.1088/1361-6471/ac0a82⟩. ⟨hal-03217611⟩
  • Janina Kopyra, Paulina Wierzbicka, Adrian Tulwin, Guillaume Thiam, Ilko Bald, et al.. Experimental and Theoretical Studies of Dissociative Electron Attachment to Metabolites Oxaloacetic and Citric Acids. International Journal of Molecular Sciences, 2021, 22 (14), pp.7676. ⟨10.3390/ijms22147676⟩. ⟨hal-03323228⟩

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