Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Observation of Forward Neutron Multiplicity Dependence of Dimuon Acoplanarity in Ultraperipheral Pb-Pb Collisions at \sqrt{s_{NN}}=5.02  TeV. Physical Review Letters, 2021, 127 (12), pp.122001. ⟨10.1103/PhysRevLett.127.122001⟩. ⟨hal-03034799⟩
  • J.-B. Salomon, R Ibata, C. Reylé, Benoit Famaey, N Libeskind, et al.. The proper motion of Andromeda from Gaia EDR3: confirming a nearly radial orbit. Monthly Notices of the Royal Astronomical Society, 2021, 507 (2), pp.2592-2601. ⟨10.1093/mnras/stab2253⟩. ⟨hal-03825962⟩
  • S. Mariazzi, R. Caravita, C. Zimmer, B. Rienäcker, A. Camper, et al.. High-yield thermalized positronium at room temperature emitted by morphologically tuned nanochanneled silicon targets. J.Phys.B, 2021, 54 (8), pp.085004. ⟨10.1088/1361-6455/abf6b6⟩. ⟨hal-03229376⟩
  • A. Addazi, K. Anderson, S. Ansell, K.S. Babu, J.L. Barrow, et al.. New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source. J.Phys.G, 2021, 48 (7), pp.070501. ⟨10.1088/1361-6471/abf429⟩. ⟨hal-02892937⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Gianluca Aglieri Rinella, et al.. First measurement of coherent ρ0 photoproduction in ultra-peripheral Xe–Xe collisions at sNN=5.44 TeV. Phys.Lett.B, 2021, 820, pp.136481. ⟨10.1016/j.physletb.2021.136481⟩. ⟨hal-03122211⟩
  • Elise Rowinski, Nicolas Magné, Jérôme Fayette, Elisabeth Daguenet, Séverine Racadot, et al.. Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub‐analysis of the ProfiLER protocol. Head & Neck, 2021, 43 (12), pp.3899-3910. ⟨10.1002/hed.26891⟩. ⟨hal-03461669⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Gianluca Aglieri Rinella, et al.. Measurements of mixed harmonic cumulants in Pb–Pb collisions at \sqrt {s_{NN}} = 5.02 TeV. Phys.Lett.B, 2021, 818, pp.136354. ⟨10.1016/j.physletb.2021.136354⟩. ⟨hal-03171343⟩
  • Janina Kopyra, Paulina Wierzbicka, Adrian Tulwin, Guillaume Thiam, Ilko Bald, et al.. Experimental and Theoretical Studies of Dissociative Electron Attachment to Metabolites Oxaloacetic and Citric Acids. International Journal of Molecular Sciences, 2021, 22 (14), pp.7676. ⟨10.3390/ijms22147676⟩. ⟨hal-03323228⟩
  • Dany Davesne, Alessandro Pastore, Jesus Navarro. Linear response theory with finite-range interactions. Progress in Particle and Nuclear Physics, 2021, 120, pp.103870. ⟨10.1016/j.ppnp.2021.103870⟩. ⟨hal-03047570⟩
  • J. Dobaczewski, P. Bączyk, P. Becker, M. Bender, K. Bennaceur, et al.. Solution of universal nonrelativistic nuclear DFT equations in the Cartesian deformed harmonic-oscillator basis. (IX) HFODD (v3.06h): a new version of the program. Journal of Physics G: Nuclear and Particle Physics, 2021, 48 (10), pp.102001. ⟨10.1088/1361-6471/ac0a82⟩. ⟨hal-03217611⟩

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