Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • M. Monteno, M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. Results from the NA50 experiment on J/\psi suppression in PbPb collisions at the CERN SPS. International Workshop on Multiparticle Production ``New Frontiers in Soft Physics and Correlations on the Threshold of the Third Millenium 9, Jun 2000, Torino, Italy. pp.43-54. ⟨in2p3-00009840⟩
  • P. Saturnini, M C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. Transverse flow in heavy ion interactions at the CERN SPS. International Workshop on Multiparticle Production 9 New Frontiers in Soft Physics and Correlations on the Threshold of the Third Millennium, Jun 2000, Torino, Italy. pp.55-61. ⟨in2p3-00009924⟩
  • A. Zaafa, J. Incharouh, M.K. Jammari, A. Boulal, R. Béraud, et al.. Tentative de description du noyau ^{125}La par la methode de couplage quasiparticule-phonon plus rotor. Rencontre Marocaine de Spectroscopie et d'Optique RMSO, Jun 2000, Casablanca, Morocco. pp.6. ⟨in2p3-00006765⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. J/\psi suppression in ultrarelativistic heavy-ion collisions. International Conference on Nuclear Reaction Mechanisms 9, Jun 2000, Varenna, Italy. ⟨in2p3-00012153⟩
  • M. Farizon, B. Farizon, F. Gobet, M.J. Gaillard, J. Martin, et al.. Agregats de biomolecules en phase gazeuse : effet des irradiations par impact de protons a l'echelle moleculaire. Molbio 2000, Jun 2000, Lyon, France. ⟨in2p3-00008143⟩
  • B. Farizon, E. Charlaix, C. Desfrancois, M. Farizon, J-P. Rieu. Regards de physiciens sur des systemes moleculaires d'interet biologique. Molbio 2000, Jun 2000, Lyon, France. pp.PM. ⟨in2p3-00009843⟩
  • A. Bauchet, I. Deloncle, M.G. Porquet, B.J.P. Gall, F. Hoellinger, et al.. High-spin structure of some neutron-rich odd-Z nuclei with A \approx 100 from heavy-ion induced fission. Structure of the Nucleus at the Down of the Century Bologna 2000, May 2000, Bologna, Italy. pp.290-293. ⟨in2p3-00013601⟩
  • G. Tabacaru, B. Borderie, M.F. Rivet, P. Chomaz, M. Colonna, et al.. Experimental evidence for spinodal decomposition in multifragmentation of heavy systems. Bologna 2000 Structure of the Nucleus at the Dawn of the Century, May 2000, Bologna, Italy. pp.321-325. ⟨in2p3-00010911⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Charmonium suppression in Pb-Pb collisions and quark-gluon deconfinement. Structure of the Nucleus at the Dawn of the Century, May 2000, Bologna, Italy. pp.91-97. ⟨in2p3-00010877⟩
  • F. Gobet, B. Farizon, M. Farizon, M.J. Gaillard, J-P. Buchet, et al.. Hydrogen cluster multifragmentation and percolation models. Bogona 2000 Structure of the Nucleus at the Dawn of the Century, May 2000, Bologna, Italy. pp.237-246. ⟨in2p3-00010885⟩

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