Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • M. Farizon. Regards de physiciens sur des systemes moleculaires d'interet biologique. Atelier Spectrometrie de Masse et Biomolecules, Jul 2000, Lyon, France. pp.PM. ⟨in2p3-00010739⟩
  • R. Grywacz, M. Lewitowicz, N.L. Achouri, J.C. Angélique, D. Baiborodin, et al.. Isomer spectroscopy of the neutron-rich nuclei near ^{70}Ni. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008286⟩
  • N. Buforn, A. Prévost, A. Astier, R. Duffait, M. Meyer, et al.. Spectroscopy of the ^{197,198}Pb superdeformed nuclei with EUROBALL IV. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008287⟩
  • A.-M. Maskay, P. Lautesse, P. Desesquelles, E. Gerlic, J.L. Laville. Ni+Ni collisions in the Fermi energy domain: experimental insight with the INDRA multidetector. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008279⟩
  • F. Barrué, S. Basnary, A. Chbihi, M. Chevallier, C. Cohen, et al.. Influence of fission barriers on scission times. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008282⟩
  • J.M. Daugas, M. Lewitowicz, N.L. Achouri, D. Baiborodin, R. Bentida, et al.. Study of neutron-rich \mus isomers towards ^{78}Ni. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008284⟩
  • J-M. Daugas, M. Lewitowicz, R. Anne, J.C. Angélique, L. Axelsson, et al.. Interplay between nuclear structure and reaction mechanism in the production of projectile-like short-lived isomers. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008285⟩
  • M. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Evidence for deconfinement from the J/\psi suppression pattern in Pb-Pb collisions by the NA50 experiment. International Conference on Quark Confinement and the Hadron Spectrum 4, Jul 2000, Vienna, Austria. pp.357-360. ⟨in2p3-00010878⟩
  • O. Drapier. Evidence for deconfinement from the J/\psi suppression pattern measured in Pb-Pb collisions at the CERN-SPS. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008278⟩
  • G. Grenier. Almost degenerate chargino-neutralino at LEP. International Conference on Supersymmetric in Physics 8 SUSY 2000, Jun 2000, Geneve, Switzerland. ⟨in2p3-00010730⟩

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