The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- A. Astier. Magnetic properties of the
j
intrudes orbital in the superdeformed minimum of
Pb. EUROBALL Collaboration Meeting, Jul 2000, Trento, Italy. ⟨in2p3-00010745⟩
- J. Gascon, Angélique Benoit, L. Berge, A. Bonnevaux, A. Broniatowski, et al.. The EDELWEISS experiment :status and outlook. International Conference on Dark Matter in Astro and Particle Physics - DARK 2000, Jul 2000, Heidelberg, Germany. pp.6. ⟨in2p3-00013521⟩
- K. Poulard. Etude de la cinetique de dissolution du zircaloy-4 - Application au stockage geologique des dechets radioactifs. Ecole Doctorale de Chimie, Jul 2000, Lyon, France. ⟨in2p3-00005590⟩
- N. Buforn, A. Astier, M. Meyer, J. Meyer, S. Perriès, et al.. Evidence for deformation in
Cd isotopes produced by heavy-ion induced fission reaction. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008288⟩
- G. Canchel, R. Béraud, E. Chabanat, A. Emsallem, N. Redon, et al.. Probing very large deformation via
-decay and electron spectroscopy in
La. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008283⟩
- G. Tabacaru, B. Borderie, M. Colonna, J-D. Frankland, Ph. Chomaz, et al.. Charge correlations in multifragmentation as a signature of spinodal instabilities. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008289⟩
- N. Buforn, A. Prévost, A. Astier, R. Duffait, M. Meyer, et al.. Spectroscopy of the
Pb superdeformed nuclei with EUROBALL IV. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008287⟩
- Y. Larochelle, L. Gingras, L. Beaulieu, P. Gagne, Z.Y. He, et al.. Isospin of intermediate mass fragment produced in peripheral mid-peripheral and central collision from the
Ni+
Ni reaction at 32A 52A and 74A MeV. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008290⟩
- N.L. Achouri, J. Aeystoe, R. Béraud, Bertram Blank, G. Canchel, et al.. The study of the beta-decay of
Al. International Conference on Collisions Nucleus Nucleus 7, Jul 2000, Strasbourg, France. ⟨in2p3-00008281⟩
- G. Chanfray. Hadrons in dense and hot matter : implications of chiral symmetry restoration. International Conference on Nucleus-Nucleus Collisions 7, Jul 2000, Strasbourg, France. pp.328-345. ⟨in2p3-00010647⟩