Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Eric Simon. Un multidétecteur pour l'étalonnage de bolomètres en énergie de recul par diffusion de neutrons dans le cadre de l'expérience EDELWEISS. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2000. Français. ⟨NNT : ⟩. ⟨tel-00001414⟩
  • F. Gobet, B. Farizon, M. Farizon, M.J. Gaillard, J-P. Buchet, et al.. Critical behaviour and hydrogen cluster multifragmentation. ECT European Center of Theoretical Physics, Sep 2000, Trento, Italy. ⟨in2p3-00008390⟩
  • M. Daoud, M. Kibler. On fractional supersymmetric quantum mechanics:the fractional supersymmetric oscillator. International School on Theoretical Physics ``Symmetry and Structural Properties of Condensed Matter'' A School devoted to the memory of Louis Michel 6, Aug 2000, Myczkowce, Poland. pp.408-421. ⟨in2p3-00009827⟩
  • R. Chehab, R. Cizeron, C. Sylvia, V. Baier, K I. Beloborodov, et al.. Experimental determination of the characteristics of a positron source using channeling. International Linear Accelerator Conference 20, Aug 2000, Monterey, United States. pp.143-145. ⟨in2p3-00008376⟩
  • F. Gieres. Supersymmetric field theories and particle physics. Conference on Fundamental Interactions in Centro-Oeste Brazil, Aug 2000, Pirenopolis, Brazil. ⟨in2p3-00010744⟩
  • F. Zach. The CMS crystal calorimeter for the LHC. ICHEP 2000, Jul 2000, Osaka, Japan. pp.3. ⟨in2p3-00006842⟩
  • M. Chemarin, H. El Mamouni, J. Fay, G. Grenier, I. Laktineh, et al.. Search for scalar leptons in e^+e^- collisions at \sqrt{s} = 192-202 GeV. International Conference on High Energy Physics 30 ICHEP 2000, Jul 2000, Osaka, Japan. ⟨in2p3-00010729⟩
  • A. Miagkov, G. Smadja. Measurement of the beauty baryon form factor. International Conference on High Energy Physics - ICHEP 2000 30, Jul 2000, Osaka, Japan. pp.17. ⟨in2p3-00005719⟩
  • P. Verdier, J. Abdallah, M. Berggren, W. da Silva, F. Kapusta, et al.. Search for supersymmetric partners of top and bottom quarks at \sqrt{s} = 192 - 202 GeV. International Conference on High Energy Physics - ICHEP 2000 30, Jul 2000, Osaka, Japan. pp.14. ⟨in2p3-00005716⟩
  • E. Anashkin, P. Checchia, A. de Min, V. Hedberg, S. Katsanevas, et al.. Update at 192-202 GeV of the analysis of photon events with missing energy. International Conference on High Energy Physics - ICHEP 2000 30, Jul 2000, Osaka, Japan. pp.17. ⟨in2p3-00005717⟩

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