Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • X. Artru. Cardan invariance of transversity cross sections - Abstract. RIKEN BNL Ressearch Center Workshop, Sep 2000, Brookhaven, United States. ⟨in2p3-00008335⟩
  • X. Artru. Transparencies - Abstract. RIKEN BNL Ressearch Center Workshop, Sep 2000, Brookhaven, United States. ⟨in2p3-00008338⟩
  • J. Meyer. Les masses : interactions effectives théories de champ moyen masses et rayons cosmiques. École thématique. Ecole Joliot Curie "Astrophysique nucléaire : du microcosme au macrocosme astrophysique", Spa, (Belgique), du 10-16 septembre 2000 : 19ème session, 2000. ⟨cel-00653820⟩
  • A. Prévost. Phenomene de superdeformation et resultats nouveaux concerannt ^{197}Pb avec EUROBALL IV. Ecole International Joliot Curie de Physique Nucleaire, Sep 2000, Spa, Belgium. ⟨in2p3-00010747⟩
  • J. Meyer. Interactions effectives theories de champ moyen masses et rayons nucleaires. Ecole Joliot Curie de Physique Nucleaire 2000 19, Sep 2000, Spa, Belgium. pp.61-67. ⟨in2p3-00009091⟩
  • Christelle Guillermier. Production d'agrégats mixtes par pulvérisation de cibles de silicium et de silice placées dans différents environnements gazeux. Physique [physics]. Université Claude Bernard - Lyon I, 2000. Français. ⟨NNT : ⟩. ⟨tel-00007701⟩
  • D. Dore, C. Volant, J. Cugnon, R. Legrain, G. Auger, et al.. Role of nucleon-nucleon collisions in the Ar+Ni reactions. International Conference on Nuclear Reaction Mechanisms 9, Sep 2000, Varenna, Italy. pp.499-507. ⟨in2p3-00007917⟩
  • P. Pawlowski, B. Borderie, G. Auger, C.O. Bacri, N. Bellaize, et al.. Contribution of prompt emissions to the production of intermediate velocity light particles in the ^{36}Ar+^{58}Ni reaction at 95 MeV/nucleon. International Conference on Nuclear Reaction Mechanisms 9, Sep 2000, Varenna, Italy. pp.509-516. ⟨in2p3-00007918⟩
  • P. Desgrolard, A. Lengyel, E. Martynov. Damping of the HERA effect in DIS ?. International Workshop on Diffraction in High Energy Physics, Sep 2000, Cetraro, Cosenza, Italy. pp.168-171. ⟨in2p3-00009777⟩
  • F. Gobet, B. Farizon, M. Farizon, M.J. Gaillard, J-P. Buchet, et al.. Hydrogen cluster multifragmentation and percolation models. ECT European Center of Theoretical Physics, Sep 2000, Trento, Italy. ⟨in2p3-00009859⟩

Powered by HAL logo