Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • GrĂ©gory Canchel. Apport de la desintegration beta a la structure de noyaux riches en protons :- ^125Ce to ^125La a l'aide d'HIGISOL- emission differee de protons du ^27S avec le spectrometre LISE. Physique NuclĂ©aire ThĂ©orique [nucl-th]. UniversitĂ© Claude Bernard - Lyon I, 2000. Français. ⟨NNT : ⟩. ⟨tel-00001422⟩
  • D. Teyssier. La recherche du boson de Higgs a LEP2 dans l'experience L3. Journees Jeunes Chercheurs 2000, Dec 2000, Saumur, France. pp.4. ⟨in2p3-00008024⟩
  • G. Moret. Recherche des oscillations neutrinos sur faisceau dans le cadre du projet OPERA. Journees Jeunes Chercheurs 2000, Dec 2000, Saumur, France. pp.4. ⟨in2p3-00008135⟩
  • A. PrĂ©vost. Nouvelles bandes excitĂ©es superdĂ©formĂ©es des plomb. - Signe d'une mollesse octupolaire près du gap N=118 Ă grande dĂ©formation. Rencontres Jeunes Chercheurs, Physique Nucleaire 6, Dec 2000, Aussois, France. ⟨in2p3-00010746⟩
  • GaĂ«lle Carlot. Diffusion de l'iode dans le zirconium : influence des Ă©lĂ©ments d'alliage et de l'hydruration. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2000. Français. ⟨NNT : ⟩. ⟨tel-00001402⟩
  • Clotilde Gaillard. Etude de la migration thermique des produits de fission molybdène, technĂ©tium et iode dans les apatites. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2000. Français. ⟨NNT : ⟩. ⟨tel-00001416⟩
  • P. Cluzel, R. Della Negra, M. Goyot, M. Miguet, A. Savoy-Navarro. Performance of a new MCM-D technology front-end digital readout. IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2000, Lyon, France. pp.7. ⟨in2p3-00013518⟩
  • J.-P. Walder, J-M. Bussat, P. Denes, H. Mathez, P. Pangaud. Custom integrated front-end circuit for the CMS electromagnetic calorimeter. IEEE Nuclear Science Symposium and Nuclear Imaging Conference, Oct 2000, Lyon, France. pp.5. ⟨in2p3-00006832⟩
  • C. Girerd, S. Gardien, J. Burch, S. Katsanevas, J. Marteau. Ethernet network-based DAQ and smart sensors for the OPERA long-baseline neutrino experiment. IEEE Nuclear Science Symposium and Nuclear Imaging Conference, Oct 2000, Lyon, France. pp.5. ⟨in2p3-00007903⟩
  • P. Depasse. Front-end electronics status of CMS electromagnetic calorimeter. Conference on Calorimetry in Particle Physics 9 CALOR 2000, Oct 2000, Annecy, France. ⟨in2p3-00006871⟩

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