Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • R. Planeta, Z. Sosin, P. Hachaj, T. Ciszek, W. Gawlikowicz, et al.. The intermediate velocity source in the ^{40}Ca + ^{197}Au reaction at 35 AMeV. Acta Physica Polonica B, 2001, 32, pp.3079-3097. ⟨in2p3-00010588⟩
  • O. Juillet, S. Fleck, L. Theussl, J.-M. Richard, K. Varga. Lower bound on fermion binding energies. Physical Review B: Condensed Matter and Materials Physics (1998-2015), 2001, 63, 073102-(4 p.). ⟨10.1103/PhysRevB.63.073102⟩. ⟨in2p3-00009762⟩
  • T. Bertrand, P. Schuck, G. Chanfray, Z. Aouissat, J. Dukelsky. Self-consistent random phase approximation in a schematic field theoretical model. Physical Review C, 2001, 63, 024301-(8 p.). ⟨10.1103/PhysRevC.63.024301⟩. ⟨in2p3-00007993⟩
  • J. Genevey, A. Gizon, P.F. Mantica, W.B. Walters, G. Marguier, et al.. Low-lying levels in ^{119}Xe. Physical Review C, 2001, 63, pp.024321-. ⟨10.1103/PhysRevC.63.024321⟩. ⟨in2p3-00007961⟩
  • A.V. Shchagin, N.A. Khiznyak, R.B. Fiorito, D.W. Rule, X. Artru. Parametric X-ray radiation for calibration of X-ray space telescopes and generation of several X-ray beams. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2001, 173, pp.154-159. ⟨10.1016/S0168-583X(00)00059-8⟩. ⟨in2p3-00024744⟩
  • M. Acciarri, P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, et al.. Measurements of the Cross Sections for Open Charm and Beauty Production in \gamma\gamma Collisions at \sqrt{s} = 189-202 GeV. Physics Letters B, 2001, 503, pp.10-20. ⟨10.1016/S0370-2693(01)00134-4⟩. ⟨in2p3-00007944⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, Z. Albrecht, et al.. Update of the search for supersymmetric particles in scenarios with Gravitino LSP and Sleptons NLSP. Physics Letters B, 2001, 503, pp.34-48. ⟨10.1016/S0370-2693(01)00207-6⟩. ⟨in2p3-00019011⟩
  • M. Ageron, A. Albert, T. Barvich, W. Beaumont, T. Beckers, et al.. Robustness test of a system of MSGC + GEM detectors at the Cyclotron facility of the Paul Scherrer Institute. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2001, 471, pp.380-391. ⟨in2p3-00009780⟩
  • A. Prévost, N. Buforn, A. Astier, R. Duffait, M. Meyer, et al.. New excited superdeformed bands in heavy Pb nuclei: Clue for an octupole softness near the N = 118 gap at large deformation. The European physical journal. A, Hadrons and Nuclei, 2001, 10, pp.13-19. ⟨in2p3-00008556⟩
  • A. Deandrea, A.D. Polosa. B \to \rho \pi decays resonant and nonresonant contributions. Physical Review Letters, 2001, 86, pp.216-219. ⟨in2p3-00010422⟩

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