Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • N. Moncoffre. Nuclear reaction spectroscopy and particle induced X-ray emission. Ecole ERASMUS: Thin Films and Multilayers as seen by Local Probes, May 2002, Frostvallen, Sweden. ⟨in2p3-00020202⟩
  • H. Kuntschner, Roland Bacon, M. Bureau, M. Cappellari, Y. Copin, et al.. SAURON: observations of E/S0/SA galaxies. Galaxy evolution : theory and observations, Apr 2002, Cozumel, Mexico. pp.199. ⟨in2p3-00024780⟩
  • D. Abbaneo, J. Alcaraz, P. Antilogus, A. Bajo-Vaquero, P. Bambade, et al.. A combination of preliminary electroweak measurements and constraints on the Standard Model. 2002. ⟨in2p3-00011434⟩
  • Daniel Teyssier. Recherche du boson de Higgs standard et non-minimal Ă  LEP2 dans l'expĂ©rience L3. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2002. Français. ⟨NNT : ⟩. ⟨tel-00001929⟩
  • O. StĂ©zowski. Excitations in the second shell. Symposium on Nuclear Structure Physics with EUROBALL: Achevements 1997-2002, Mar 2002, Orsay, France. ⟨in2p3-00020315⟩
  • G.-S. Muanza. New phenomena searches at Tevatron Run I. Rencontres de Moriond : QCD and Hadronic Interactions at High Energy 37, Mar 2002, Les Arcs, France. pp.20. ⟨in2p3-00013755⟩
  • G.-S. Muanza. Searches at the TEVATRON. Rencontres de Moriond: QCD and Hadronic Interactions at High Energy 37, Mar 2002, Les Arcs, France. ⟨in2p3-00020287⟩
  • D. Teyssier, G.-S. Muanza, P. Lebrun. Search for the Standard Model Higgs boson in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. Rencontres de Moriond: QCD and Hadronic Interactions at High Energy 37, Mar 2002, Les Arcs, France. ⟨in2p3-00020297⟩
  • G.-S. Muanza, P. Lebrun, D. Teyssier. Search for invisible Higgs boson decay in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. Rencontres de Moriond: QCD and Hadronic Interactions at High Energy 37, Mar 2002, Les Arcs, France. ⟨in2p3-00020298⟩
  • P. Antilogus. Nearby SuperNova factory. Rencontres de Moriond : The Cosmological Model, Mar 2002, Les Arcs, France. pp.4. ⟨in2p3-00020144⟩

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