Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Jérémie Llodra-Perez. Effective Models of new physics at the Large Hadron Collider. Other [cond-mat.other]. Université Claude Bernard - Lyon I, 2011. English. ⟨NNT : 2011LYO10127⟩. ⟨tel-00610216v2⟩
  • D. Tsimpis. Uses of 3d toric varieties. Conférence plénière annuelle de la théorie des cordes, Strings 2011, Jun 2011, Uppsala, Sweden. ⟨in2p3-00972019⟩
  • J. Gironnet. EDELWEISS dark matter search: Latest results and future plans. 7th Patras Workshop on Axions, WIMPs and WISPs, Jun 2011, Mykonos, Greece. ⟨10.3204/DESY-PROC-2011-04/gironnet_johann⟩. ⟨in2p3-00746520⟩
  • M. Rigault, Y. Copin, G. Aldering, P. Antilogus, C. Aragon, et al.. Local host galaxy properties of type Ia supernovae from the Nearby SuperNovae Factory. Journées 2011 de la Société Française d'Astronomie & d'Astrophysique (SF2A), Jun 2011, Paris, France. pp.179-183. ⟨in2p3-00763308⟩
  • B. Censier. Review on non-directional direct dark matter searches. Third International Conference on Directional of Dark Matter - CYGNUS 2011, Jun 2011, Aussois, France. ⟨in2p3-00628691⟩
  • I. Laktineh. Construction of a technological semi-digital hadronic calorimeter. Technology and Instrumentation in Particle Physics 2011 (TIPP 2011) conference, Jun 2011, Chicago, United States. ⟨in2p3-00972059⟩
  • I. Laktineh, N. Lumb, R. Kieffer, J.-C. Ianigro, L. Mirabito, et al.. Development of large and very thin GRPCs with new resistive coating and new gas distribution scheme. Technology and Instrumentation in Particle Physics 2011 (TIPP 2011) conference, Jun 2011, Chicago, United States. ⟨in2p3-00972075⟩
  • M.M. Harb, C. Montano, V. Buridon, K. El Farkh, C. Teyssier, et al.. Host-guest chemistry investigated by mass spectrometry: which do 3iPO phospho-cavitand like best Choline or Acetylcholine ?. 59th ASMS Conference on Mass Spectrometry and allied Topics, Jun 2011, Denver, United States. ⟨in2p3-00781867⟩
  • K. El Farkh, G. Bruny, V. Buridon, S. Feil, M.M. Harb, et al.. Number of a fragment spectrometry in CID of mass selected ions: a new tool for ion characterization in the MS-MS frame. 59th ASMS Conference on Mass Spectrometry and allied Topics, Jun 2011, Denver, United States. ⟨in2p3-00781850⟩
  • V. Buridon, K. El Farkh, M.M. Harb, C. Teyssier, H. Abdoul-Carime, et al.. Identification of the neutral products in CID via analysis of the distributions of their output signal amplitude at the detector. 59th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 2011, Denver, United States. ⟨in2p3-00745706⟩

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