Health (PRISME)

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  • Activities
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  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • H.M. Courtois, R. Brent Tully, P. Héraudeau. Cosmic flows: University of Hawaii 2.2-m I-band photometry. Monthly Notices of the Royal Astronomical Society, 2011, 415, pp.1935-1942. ⟨10.1111/J.1365-2966.2011.18839.X⟩. ⟨in2p3-00631731⟩
  • Sacha Davidson, V. Sanz. Non standard neutrino interactions at LEP2 and the LHC. NUFACT 11 : XIIIth InternationalWorkshop on Neutrino Factories, Super Beams and Beta beams, Aug 2011, Genève, Switzerland. pp.012033, ⟨10.1088/1742-6596/408/1/012033⟩. ⟨in2p3-00630425⟩
  • M. Martini. Two particle-two hole excitations in charged current quasielastic neutrino-nucleus interactions. XIII International Workshop on Neutrino Factories, Super beams and Beta beams (NUFACT11), Aug 2011, Genève, Switzerland. pp.012041, ⟨10.1088/1742-6596/408/1/012041⟩. ⟨in2p3-00976842⟩
  • A. Juillard. Status and Prospects of the EDELWEISS Direct WIMP Search Experiment. 14th International Workshop on Low Temperature Detectors (LTD14), Aug 2011, Heidelberg, Germany. pp.1056-1062, ⟨10.1007/s10909-012-0512-z⟩. ⟨in2p3-00702704⟩
  • N. Chotard. The reddening law of type Ia Supernovae. XXIst International Europhysics Conference on High Energy Physics - HEP2011, Jul 2011, Grenoble, France. pp.081. ⟨in2p3-00700826⟩
  • J. Gascon. Status and prospects of the EDELWEISS direct WIMP search. XXIst International Europhysics Conference on High Energy Physics - HEP2011, Jul 2011, Grenoble, France. pp.057. ⟨in2p3-00700828⟩
  • Pierre Henriquet. Etude de l'émission de particules chargées secondaires dans l'optique d'un monitorage faisceau et de la dosimétrie en ligne en hadronthérapie. Physique Médicale [physics.med-ph]. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : ⟩. ⟨tel-00712778⟩
  • A. Dominjon, M. Ageron, R. Barbier, M. Billault, J. Brunner, et al.. An ebCMOS camera system for marine bioluminescence observation: The LuSEApher prototype. 6th International Conference on New Developements in Photodetection (NDIP 2011), Jul 2011, Lyon, France. pp.172-178, ⟨10.1016/j.nima.2011.11.048⟩. ⟨in2p3-00660470⟩
  • S. Beauceron. The CMS High Level Trigger. 36th International Conference for High Energy Physics (ICHEP 2012), Jul 2011, Melbourne, Australia. pp.505. ⟨in2p3-00967135⟩
  • C. Guérin, J. Mahroug, W. Tromeur, J. Houles, P. Calabria, et al.. An acquisition system for CMOS imagers with a genuine 10 Gbit/s bandwidth. 6th International Conference on New Developements in Photodetection (NDIP 2011), Jul 2011, Lyon, France. pp.420-424, ⟨10.1016/j.nima.2011.11.003⟩. ⟨in2p3-00745078⟩

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