Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • A. Uras. Light Neutral Mesons Production in p-A Collisions at \sqrt {s} = 27.5 GeV with the NA60 Experiment. Strangeness in Quark Matter 2011, Sep 2011, Warsaw, Poland. pp.465-470, ⟨10.5506/APhysPolBSupp.5.465⟩. ⟨in2p3-00689910⟩
  • N. Wehbe, M. Fallavier, S. Della Negra. Ion emission statistics under gold cluster impact. 18th International Conference on "Secondary Ion Mass Spectrometry, Sep 2011, Riva del Garda, Italy. ⟨in2p3-00777816⟩
  • A. Novikov, M. Caroff, M. Pautrat, M. Fallavier, S. Della Negra. The Aun cluster probe in SIMS analysis of bacterial lipid A. 18th International Conference on "Secondary Ion Mass Spectrometry, Sep 2011, Riva del Garda, Italy. ⟨in2p3-00777821⟩
  • L. Massacrier. Vector Meson Production in the Dimuon Channel in the ALICE Experiment at the LHC. Strangeness in Quark Matter 2011, Sep 2011, Kraków, Poland. pp.477-482, ⟨10.5506/APhysPolBSupp.5.477⟩. ⟨in2p3-00690343⟩
  • P. Costa, C.A. de Sousa, M.C. Ruivo, H. Hansen. The QCD Critical End Point in the Context of the Polyakov-Nambu-Jona-Lasinio Model. Strangeness in Quark Matter 2011, Sep 2011, Kraków, Poland. pp.523-528, ⟨10.5506/APhysPolBSupp.5.523⟩. ⟨in2p3-00690341⟩
  • T. Thuillier, J. Angot, C. Barué, C. Canet, T. Lamy, et al.. Roadmap for the design of a superconducting electron cyclotron resonance ion source for Spiral2. 14th International Conference on Ion Sources - ICIS 2011, Sep 2011, Giardini Naxos, Italy. AIP Press, 83, pp.02A339, 2012, ⟨10.1063/1.3673004⟩. ⟨in2p3-00623258⟩
  • P. Lehérissier, O. Bajeat, C. Barué, C. Canet, M. Dubois, et al.. Status of the ion sources developments for SPIRAL2 at GANIL. 14th International Conference on Ion Sources - ICIS 2011, Sep 2011, Giardini Naxos, Italy. 83, pp.02A915, 2012, ⟨10.1063/1.3678677⟩. ⟨in2p3-00622149⟩
  • O. Dadoun, G. Le Meur, F. Touze, A. Variola, X. Artru, et al.. An event generator for crystal source Application of the CLIC positron baseline. IX International Symposium "Radiation from Relativistic Electrons in Periodic Structures (RREPS-11), Sep 2011, Egham, United Kingdom. pp.012024, ⟨10.1088/1742-6596/357/1/012024⟩. ⟨in2p3-00740837⟩
  • G. Bertrand, M. Maalouf, P. Battiston-Montagne, M. Beuve, Clarisse Fournier, et al.. Ciblage des cellules souches cancéreuses, une étape essentielle pour augmenter l'efficacité de la radiothérapie dans les cancers épidermoÏdes de la tête et du cou. 10th CIRFA, Sep 2011, Anglet, France. ⟨in2p3-00773091⟩
  • O. Stézowski. MBS/Narval Filter. AGATA Week, Sep 2011, Darmstadt, Germany. ⟨in2p3-00990103⟩

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