Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • M. La Commara, S. Pirrone, G. Politi, J.P. Wieleczko, G. Ademard, et al.. Decay modes of the systems formed in the reactions 78Kr+40Ca and 86Kr+48Ca. International Workshop on Multifragmentation and Related Topics - IWM2011, Nov 2011, Caen, France. pp.00022, ⟨10.1051/epjconf/20123100022⟩. ⟨in2p3-00717128⟩
  • J. Marteau. Le Neutrino, pas si ElĂ©mentaire. ConfĂ©rence du DĂ©partement de Physique de l'ENS de Lyon, Nov 2011, Lyon, France. ⟨in2p3-00772510⟩
  • Laure Massacrier. La physique des (di)muons dans ALICE au LHC : analyse en collisions pp (√s = 7 TeV) et Pb-Pb (√sNN = 2.76 TeV) des rĂ©sonances de basses masses (ρ, ω, ф) et Ă©tude d’un trajectographe en pixels de Silicium dans l’ouverture du spectromĂštre. Autre [cond-mat.other]. UniversitĂ© Claude Bernard - Lyon I, 2011. Français. ⟨NNT : 2011LYO10203⟩. ⟨tel-00800827v2⟩
  • X. Artru, Z. Belghobsi. String model for spinning quark jets. 8th International Conference on Progress in Theoretical Physics, Oct 2011, Constantine, Algeria. pp.97-105, ⟨10.1063/1.4715403⟩. ⟨in2p3-00766469⟩
  • B. Golosio, Z. Abou-Haidar, C. Agodi, M.A.G. Alvarez, T. Aumann, et al.. The FIRST experiment for nuclear fragmentation measurements at GSI. IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011, Oct 2011, Valencia, Spain. pp.2277-2280, ⟨10.1109/NSSMIC.2011.6153861⟩. ⟨in2p3-00691864⟩
  • E. Redouane-Salah, X. Artru. Stark ionisation of hydrogen in the n=2 level. Asymmetry in the final transverse velocity. 8th International Workshop on Progress in Theoretical Physics (ICPTP 2011), Oct 2011, Constantine, Algeria. pp.157-161, ⟨10.1063/1.4715411⟩. ⟨in2p3-00672604⟩
  • M.-H. Richard, D. Dauvergne, M. Dahoumane, N. Freud, J.M. LĂ©tang, et al.. Design of a Compton Camera for On-line Control in Ion Beam Therapy Using Geant4 design study of the absorber detector. 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference, Oct 2011, Valence, Spain. ⟨in2p3-00778028⟩
  • D. Autiero. Measurement of the neutrino velocity with the OPERA detector in the CNGS beam. Conseil scientifique de l'IN2P3, Oct 2011, Paris, France. ⟨in2p3-01019689⟩
  • H. Brun. Standard Model Higgs Boson Searches from CMS. Workshop on Searches for Supersymmetry at the LHC, Oct 2011, Berkeley, United States. ⟨in2p3-01018351⟩
  • D. Benjamin, M. Herndon, E. James, T. Junk, N. Krumnack, et al.. Combined CDF and D0 Searches for the Standard Model Higgs Boson Decaying to Two Photons with up to 8.2 fb^-1. 2011. ⟨in2p3-00631106⟩

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